NC-Reg : Neural Cortical Maps for Rigid Registration

We introduce neural cortical maps, a continuous and compact neural representation for cortical feature maps, as an alternative to traditional discrete structures such as grids and meshes. It can learn from meshes of arbitrary size and provide learnt features at any resolution. Neural cortical maps enable efficient optimization on the sphere and achieve runtimes up to 30 times faster than classic barycentric interpolation (for the same number of iterations). As a proof of concept, we investigate rigid registration of cortical surfaces and propose NC-Reg, a novel iterative algorithm that involves the use of neural cortical feature maps, gradient descent optimization and a simulated annealing strategy. Through ablation studies and subject-to-template experiments, our method demonstrates sub-degree accuracy ($<1^\circ$ from the global optimum), and serves as a promising robust pre-alignment strategy, which is critical in clinical settings.

Standardized Evaluation of Automatic Methods for Perivascular Spaces Segmentation in MRI -- MICCAI 2024 Challenge Results

Perivascular spaces (PVS), when abnormally enlarged and visible in magnetic resonance imaging (MRI) structural sequences, are important imaging markers of cerebral small vessel disease and potential indicators of neurodegenerative conditions. Despite their clinical significance, automatic enlarged PVS (EPVS) segmentation remains challenging due to their small size, variable morphology, similarity with other pathological features, and limited annotated datasets. This paper presents the EPVS Challenge organized at MICCAI 2024, which aims to advance the development of automated algorithms for EPVS segmentation across multi-site data. We provided a diverse dataset comprising 100 training, 50 validation, and 50 testing scans collected from multiple international sites (UK, Singapore, and China) with varying MRI protocols and demographics. All annotations followed the STRIVE protocol to ensure standardized ground truth and covered the full brain parenchyma. Seven teams completed the full challenge, implementing various deep learning approaches primarily based on U-Net architectures with innovations in multi-modal processing, ensemble strategies, and transformer-based components. Performance was evaluated using dice similarity coefficient, absolute volume difference, recall, and precision metrics. The winning method employed MedNeXt architecture with a dual 2D/3D strategy for handling varying slice thicknesses. The top solutions showed relatively good performance on test data from seen datasets, but significant degradation of performance was observed on the previously unseen Shanghai cohort, highlighting cross-site generalization challenges due to domain shift. This challenge establishes an important benchmark for EPVS segmentation methods and underscores the need for the continued development of robust algorithms that can generalize in diverse clinical settings.