Accelerating Posterior Inference from Pulsar Light Curves via Learned Latent Representations and Local Simulator-Guided Optimization

Posterior inference from pulsar observations in the form of light curves is commonly performed using Markov chain Monte Carlo methods, which are accurate but computationally expensive. We introduce a framework that accelerates posterior inference while maintaining accuracy by combining learned latent representations with local simulator-guided optimization. A masked U-Net is first pretrained to reconstruct complete light curves from partial observations and to produce informative latent embeddings. Given a query light curve, we identify similar simulated light curves from the simulation bank by measuring similarity in the learned embedding space produced by pretrained U-Net encoder, yielding an initial empirical approximation to the posterior over parameters. This initialization is then refined using a local optimization procedure using hill-climbing updates, guided by a forward simulator, progressively shifting the empirical posterior toward higher-likelihood parameter regions. Experiments on the observed light curve of PSR J0030+0451, captured by NASA's Neutron Star Interior Composition Explorer (NICER), show that our method closely matches posterior estimates obtained using traditional MCMC methods while achieving 120 times reduction in inference time (from 24 hours to 12 minutes), demonstrating the effectiveness of learned representations and simulator-guided optimization for accelerated posterior inference.

Diabetic Retinopathy Classification from Retinal Images using Machine Learning Approaches

Diabetic Retinopathy is one of the most familiar diseases and is a diabetes complication that affects eyes. Initially, diabetic retinopathy may cause no symptoms or only mild vision problems. Eventually, it can cause blindness. So early detection of symptoms could help to avoid blindness. In this paper, we present some experiments on some features of diabetic retinopathy, like properties of exudates, properties of blood vessels and properties of microaneurysm. Using the features, we can classify healthy, mild non-proliferative, moderate non-proliferative, severe non-proliferative and proliferative stages of DR. Support Vector Machine, Random Forest and Naive Bayes classifiers are used to classify the stages. Finally, Random Forest is found to be the best for higher accuracy, sensitivity and specificity of 76.5%, 77.2% and 93.3% respectively.