Cuffless, calibration-free hemodynamic monitoring with physics-informed machine learning models

Wearable technologies have the potential to transform ambulatory and at-home hemodynamic monitoring by providing continuous assessments of cardiovascular health metrics and guiding clinical management. However, existing cuffless wearable devices for blood pressure (BP) monitoring often rely on methods lacking theoretical foundations, such as pulse wave analysis or pulse arrival time, making them vulnerable to physiological and experimental confounders that undermine their accuracy and clinical utility. Here, we developed a smartwatch device with real-time electrical bioimpedance (BioZ) sensing for cuffless hemodynamic monitoring. We elucidate the biophysical relationship between BioZ and BP via a multiscale analytical and computational modeling framework, and identify physiological, anatomical, and experimental parameters that influence the pulsatile BioZ signal at the wrist. A signal-tagged physics-informed neural network incorporating fluid dynamics principles enables calibration-free estimation of BP and radial and axial blood velocity. We successfully tested our approach with healthy individuals at rest and after physical activity including physical and autonomic challenges, and with patients with hypertension and cardiovascular disease in outpatient and intensive care settings. Our findings demonstrate the feasibility of BioZ technology for cuffless BP and blood velocity monitoring, addressing critical limitations of existing cuffless technologies.

Online Learning and Optimization for Revenue Management Problems with Add-on Discounts

We study in this paper a revenue management problem with add-on discounts. The problem is motivated by the practice in the video game industry, where a retailer offers discounts on selected supportive products (e.g. video games) to customers who have also purchased the core products (e.g. video game consoles). We formulate this problem as an optimization problem to determine the prices of different products and the selection of products with add-on discounts. To overcome the computational challenge of this optimization problem, we propose an efficient FPTAS algorithm that can solve the problem approximately to any desired accuracy. Moreover, we consider the revenue management problem in the setting where the retailer has no prior knowledge of the demand functions of different products. To resolve this problem, we propose a UCB-based learning algorithm that uses the FPTAS optimization algorithm as a subroutine. We show that our learning algorithm can converge to the optimal algorithm that has access to the true demand functions, and we prove that the convergence rate is tight up to a certain logarithmic term. In addition, we conduct numerical experiments with the real-world transaction data we collect from a popular video gaming brand's online store on Tmall.com. The experiment results illustrate our learning algorithm's robust performance and fast convergence in various scenarios. We also compare our algorithm with the optimal policy that does not use any add-on discount, and the results show the advantages of using the add-on discount strategy in practice.