STEDiff: Strengthening Text Embedding for Text-to-Image Alignment in Diffusion Model

Although pretrained text-to-image (T2I) generation models can produce high-quality images, they often fail to faithfully reflect the semantic intent of complex prompts due to stochastic noise and inherent model limitations. This issue frequently manifests as the model overlooking specific objects or failing to correctly bind attributes to their corresponding entities, a challenge referred to as semantic alignment. Unlike existing approaches that rely on computationally expensive fine-tuning or labor-intensive layout priors, we propose STEDiff, a training-free method designed to enhance semantic representations directly within the text-embedding space. Specifically, we introduce a method that primarily leverages the [EOT] token to strengthen the relevant semantics of sub-sentences and then replaces the corresponding tokens in the original prompt. Furthermore, a novel semantic enhancement loss is incorporated to enforce spatial constraints, ensuring that the semantics of each entity are precisely mapped to their respective image regions. Extensive quantitative and qualitative evaluations on the T2I-CompBench demonstrate that our method notably improves semantic consistency and generation integrity in complex scenarios.

Solitary pulmonary nodules prediction for lung cancer patients using nomogram and machine learning

Lung cancer(LC) is a type of malignant neoplasm that originates in the bronchial mucosa or glands.As a clinically common nodule,solitary pulmonary nodules(SPNs) have a significantly higher probability of malignancy when they are larger than 8 mm in diameter.But there is also a risk of lung cancer when the diameter is less than 8mm,the purpose of this study was to create a nomogram for estimating the likelihood of lung cancer in patients with SPNs of 8 mm or smaller using computed tomography(CT) scans and biomarker information.Use CT scans and various biomarkers as input to build predictive models for the likelihood of lung cancer in patients with SPNs of 8 mm or less.The age,precursor gastrin-releasing peptide (ProGRP),gender,Carcinoembryonic Antigen(CEA),and stress corrosion cracking(SCC) were independent key tumor markers and were entered into the nomogram.The developed nomogram demonstrated strong accuracy in predicting lung cancer risk,with an internal validation area under the receiver operating characteristics curve(ROC) of 0.8474.The calibration curves plotted showed that the nomogram predicted the probability of lung cancer with good agreement with the actual probability.In this study,we finally succeeded in constructing a suitable nomogram that could predict the risk of lung cancer in patients with SPNs<=8 mm in diameter.The model has a high level of accuracy and is able to accurately distinguish between different patients,allowing clinicians to develop personalized treatment plans for individuals with SPNs.