Hallucination Detection-Guided Preference Optimization for Clinical Summarization

Large language models (LLMs) have shown promise on summarization tasks, but they often produce hallucinations, which are unsupported or incorrect statements that limit their reliability in specialized healthcare applications. We introduce \itermodelfull (\itermodel), an inference-time method that leverages hallucination detectors to guide iterative summary revisions toward factual corrections. Building on this, we propose \itermodel for Preference Learning (\model), which converts detector-guided refinement trajectories into preference pairs for model finetuning. Extensive experiments show that our methods substantially reduce hallucinations for Llama and Gemma models in summarizing real-world clinical notes from \MimicIV. For example, \itermodel reduces 24\% and \model reduces 48\% hallucinations in Llama-3.1-8B-Instruct. Importantly, both methods preserve summary fluency, coherence, and relevance according to human expert and LLM-Jury evaluations. Together, these results demonstrate that detection-informed refinement and preference learning offer an automated solution for improving factual faithfulness in clinical summarization.

ACR: A Benchmark for Automatic Cohort Retrieval

Identifying patient cohorts is fundamental to numerous healthcare tasks, including clinical trial recruitment and retrospective studies. Current cohort retrieval methods in healthcare organizations rely on automated queries of structured data combined with manual curation, which are time-consuming, labor-intensive, and often yield low-quality results. Recent advancements in large language models (LLMs) and information retrieval (IR) offer promising avenues to revolutionize these systems. Major challenges include managing extensive eligibility criteria and handling the longitudinal nature of unstructured Electronic Medical Records (EMRs) while ensuring that the solution remains cost-effective for real-world application. This paper introduces a new task, Automatic Cohort Retrieval (ACR), and evaluates the performance of LLMs and commercial, domain-specific neuro-symbolic approaches. We provide a benchmark task, a query dataset, an EMR dataset, and an evaluation framework. Our findings underscore the necessity for efficient, high-quality ACR systems capable of longitudinal reasoning across extensive patient databases.