Counterfactual Understanding via Retrieval-aware Multimodal Modeling for Time-to-Event Survival Prediction

This paper tackles the problem of time-to-event counterfactual survival prediction, aiming to optimize individualized survival outcomes in the presence of heterogeneity and censored data. We propose CURE, a framework that advances counterfactual survival modeling via comprehensive multimodal embedding and latent subgroup retrieval. CURE integrates clinical, paraclinical, demographic, and multi-omics information, which are aligned and fused through cross-attention mechanisms. Complex multi-omics signals can be adaptively refined using a mixture-of-experts architecture, emphasizing the most informative omics components. Building upon this representation, CURE implicitly retrieves patient-specific latent subgroups that capture both baseline survival dynamics and treatment-dependent variations. Experimental results on METABRIC and TCGA-LUAD datasets demonstrate that proposed CURE model consistently outperforms strong baselines in survival analysis, evaluated using the Time-dependent Concordance Index ($C^{td}$) and Integrated Brier Score (IBS). These findings highlight the potential of CURE to enhance multimodal understanding and serve as a foundation for future treatment recommendation models. All code and related resources are publicly available to facilitate the reproducibility https://github.com/L2R-UET/CURE.

Multi-modal Adaptive Mixture of Experts for Cold-start Recommendation

Recommendation systems have faced significant challenges in cold-start scenarios, where new items with a limited history of interaction need to be effectively recommended to users. Though multimodal data (e.g., images, text, audio, etc.) offer rich information to address this issue, existing approaches often employ simplistic integration methods such as concatenation, average pooling, or fixed weighting schemes, which fail to capture the complex relationships between modalities. Our study proposes a novel Mixture of Experts (MoE) framework for multimodal cold-start recommendation, named MAMEX, which dynamically leverages latent representation from different modalities. MAMEX utilizes modality-specific expert networks and introduces a learnable gating mechanism that adaptively weights the contribution of each modality based on its content characteristics. This approach enables MAMEX to emphasize the most informative modalities for each item while maintaining robustness when certain modalities are less relevant or missing. Extensive experiments on benchmark datasets show that MAMEX outperforms state-of-the-art methods in cold-start scenarios, with superior accuracy and adaptability. For reproducibility, the code has been made available on Github https://github.com/L2R-UET/MAMEX.