Functional MRI Time Series Generation via Wavelet-Based Image Transform and Spectral Flow Matching for Brain Disorder Identification

Functional Magnetic Resonance Imaging (fMRI) provides non-invasive access to dynamic brain activity by measuring blood oxygen level-dependent (BOLD) signals over time. However, the resource-intensive nature of fMRI acquisition limits the availability of high-fidelity samples required for data-driven brain analysis models. While modern generative models can synthesize fMRI data, they often remain challenging in replicating their inherent non-stationarity, intricate spatiotemporal dynamics, and physiological variations of raw BOLD signals. To address these challenges, we propose Dual-Spectral Flow Matching (DSFM), a novel fMRI generative framework that cascades dual frequency representation of BOLD signals with spectral flow matching. Specifically, our framework first converts BOLD signals into a wavelet decomposition map via a discrete wavelet transform (DWT) to capture globalized transient and multi-scale variations, and projects into the discrete cosine transform (DCT) space across brain regions and time to exploit localized energy compaction of low-frequency dominant BOLD coefficients. Subsequently, a spectral flow matching model is trained to generate class-conditioned cosine-frequency representation. The generated samples are reconstructed through inverse DCT and inverse DWT operations to recover physiologically plausible time-domain BOLD signals. This dual-transform approach imposes structured frequency priors and preserves key physiological brain dynamics. Ultimately, we demonstrate the efficacy of our approach through improved downstream fMRI-based brain network classification. The code is available at https://github.com/htew0001/DSFM.git .

Physics-Informed Deformable Gaussian Splatting: Towards Unified Constitutive Laws for Time-Evolving Material Field

Recently, 3D Gaussian Splatting (3DGS), an explicit scene representation technique, has shown significant promise for dynamic novel-view synthesis from monocular video input. However, purely data-driven 3DGS often struggles to capture the diverse physics-driven motion patterns in dynamic scenes. To fill this gap, we propose Physics-Informed Deformable Gaussian Splatting (PIDG), which treats each Gaussian particle as a Lagrangian material point with time-varying constitutive parameters and is supervised by 2D optical flow via motion projection. Specifically, we adopt static-dynamic decoupled 4D decomposed hash encoding to reconstruct geometry and motion efficiently. Subsequently, we impose the Cauchy momentum residual as a physics constraint, enabling independent prediction of each particle's velocity and constitutive stress via a time-evolving material field. Finally, we further supervise data fitting by matching Lagrangian particle flow to camera-compensated optical flow, which accelerates convergence and improves generalization. Experiments on a custom physics-driven dataset as well as on standard synthetic and real-world datasets demonstrate significant gains in physical consistency and monocular dynamic reconstruction quality.