Prob-BBDM: a Probabilistic Brownian Bridge Diffusion Model for MRI sequence image-to-image translation

AI-driven image-to-image synthesis is rapidly advancing, with growing applications in medical imaging. Multi-modal image analysis plays a crucial role in optimizing examination quality, yet acquiring multiple imaging modalities in clinical settings remains resource-intensive and time-consuming, especially for 3D imaging. To address this challenge, we propose a novel image-to-image translation model based on Brownian Bridge Diffusion Models (BBDM), which synthesizes magnetic resonance imaging (MRI) sequences from 2D axial slices. Our approach integrates a variational encoder-guided diffusion mechanism, leveraging probabilistic image distributions to enhance synthesis quality. Evaluated on the BraTS 2021 dataset, our Probabilistic-BBDM (Prob-BBDM) achieves superior performance across multiple translation tasks, reaching up to 88.46% SSIM and 26.09 dB PSNR, with consistent improvements over baselines. Notably, our diffusion process requires only 4 steps, making it computationally efficient while maintaining high-quality synthesis. To further validate generalizability, we test Prob-BBDM on an external third-party dataset, demonstrating consistent performance across domains. Additionally, we assess the clinical utility of the synthesized slices by using them as input to a pre-trained segmentation model. Tumor segmentation yields a Dice score of 88.71% and an HD95 of 3.49 mm, confirming that the synthesized slices preserve critical diagnostic information. These results highlight the potential of Prob-BBDM for high-quality, efficient, and generalizable MRI synthesis, offering a promising step toward improved medical image translation.

Explainable AI in Biomedical Signal and Image Processing: Promises and Challenges

Artificial intelligence has become pervasive across disciplines and fields, and biomedical image and signal processing is no exception. The growing and widespread interest on the topic has triggered a vast research activity that is reflected in an exponential research effort. Through study of massive and diverse biomedical data, machine and deep learning models have revolutionized various tasks such as modeling, segmentation, registration, classification and synthesis, outperforming traditional techniques. However, the difficulty in translating the results into biologically/clinically interpretable information is preventing their full exploitation in the field. Explainable AI (XAI) attempts to fill this translational gap by providing means to make the models interpretable and providing explanations. Different solutions have been proposed so far and are gaining increasing interest from the community. This paper aims at providing an overview on XAI in biomedical data processing and points to an upcoming Special Issue on Deep Learning in Biomedical Image and Signal Processing of the IEEE Signal Processing Magazine that is going to appear in March 2022.