An Uncertainty Aided Framework for Learning based Liver $T_1ρ$ Mapping and Analysis

Objective: Quantitative $T_1\rho$ imaging has potential for assessment of biochemical alterations of liver pathologies. Deep learning methods have been employed to accelerate quantitative $T_1\rho$ imaging. To employ artificial intelligence-based quantitative imaging methods in complicated clinical environment, it is valuable to estimate the uncertainty of the predicated $T_1\rho$ values to provide the confidence level of the quantification results. The uncertainty should also be utilized to aid the post-hoc quantitative analysis and model learning tasks. Approach: To address this need, we propose a parametric map refinement approach for learning-based $T_1\rho$ mapping and train the model in a probabilistic way to model the uncertainty. We also propose to utilize the uncertainty map to spatially weight the training of an improved $T_1\rho$ mapping network to further improve the mapping performance and to remove pixels with unreliable $T_1\rho$ values in the region of interest. The framework was tested on a dataset of 51 patients with different liver fibrosis stages. Main results: Our results indicate that the learning-based map refinement method leads to a relative mapping error of less than 3% and provides uncertainty estimation simultaneously. The estimated uncertainty reflects the actual error level, and it can be used to further reduce relative $T_1\rho$ mapping error to 2.60% as well as removing unreliable pixels in the region of interest effectively. Significance: Our studies demonstrate the proposed approach has potential to provide a learning-based quantitative MRI system for trustworthy $T_1\rho$ mapping of the liver.

Uncertainty-weighted Multi-tasking for $T_{1ρ}$ and T$_2$ Mapping in the Liver with Self-supervised Learning

Multi-parametric mapping of MRI relaxations in liver has the potential of revealing pathological information of the liver. A self-supervised learning based multi-parametric mapping method is proposed to map T$T_{1\rho}$ and T$_2$ simultaneously, by utilising the relaxation constraint in the learning process. Data noise of different mapping tasks is utilised to make the model uncertainty-aware, which adaptively weight different mapping tasks during learning. The method was examined on a dataset of 51 patients with non-alcoholic fatter liver disease. Results showed that the proposed method can produce comparable parametric maps to the traditional multi-contrast pixel wise fitting method, with a reduced number of images and less computation time. The uncertainty weighting also improves the model performance. It has the potential of accelerating MRI quantitative imaging.

Uncertainty-Aware Self-supervised Neural Network for Liver $T_{1ρ}$ Mapping with Relaxation Constraint

$T_{1\rho}$ mapping is a promising quantitative MRI technique for the non-invasive assessment of tissue properties. Learning-based approaches can map $T_{1\rho}$ from a reduced number of $T_{1\rho}$ weighted images, but requires significant amounts of high quality training data. Moreover, existing methods do not provide the confidence level of the $T_{1\rho}$ estimation. To address these problems, we proposed a self-supervised learning neural network that learns a $T_{1\rho}$ mapping using the relaxation constraint in the learning process. Epistemic uncertainty and aleatoric uncertainty are modelled for the $T_{1\rho}$ quantification network to provide a Bayesian confidence estimation of the $T_{1\rho}$ mapping. The uncertainty estimation can also regularize the model to prevent it from learning imperfect data. We conducted experiments on $T_{1\rho}$ data collected from 52 patients with non-alcoholic fatty liver disease. The results showed that our method outperformed the existing methods for $T_{1\rho}$ quantification of the liver using as few as two $T_{1\rho}$-weighted images. Our uncertainty estimation provided a feasible way of modelling the confidence of the self-supervised learning based $T_{1\rho}$ estimation, which is consistent with the reality in liver $T_{1\rho}$ imaging.

Event-based Timestamp Image Encoding Network for Human Action Recognition and Anticipation

Event camera is an asynchronous, high frequency vision sensor with low power consumption, which is suitable for human action understanding task. It is vital to encode the spatial-temporal information of event data properly and use standard computer vision tool to learn from the data. In this work, we propose a timestamp image encoding 2D network, which takes the encoded spatial-temporal images with polarity information of the event data as input and output the action label. In addition, we propose a future timestamp image generator to generate futureaction information to aid the model to anticipate the human action when the action is not completed. Experiment results show that our method can achieve the same level of performance as those RGB-based benchmarks on real world action recognition,and also achieve the state of the art (SOTA) result on gesture recognition. Our future timestamp image generating model can effectively improve the prediction accuracy when the action is not completed. We also provide insight discussion on the importance of motion and appearance information in action recognition and anticipation.

Event-based Action Recognition Using Timestamp Image Encoding Network

Event camera is an asynchronous, high frequency vision sensor with low power consumption, which is suitable for human action recognition task. It is vital to encode the spatial-temporal information of event data properly and use standard computer vision tool to learn from the data. In this work, we propose a timestamp image encoding 2D network, which takes the encoded spatial-temporal images of the event data as input and output the action label. Experiment results show that our method can achieve the same level of performance as those RGB-based benchmarks on real world action recognition, and also achieve the SOTA result on gesture recognition.

A Genetic Feature Selection Based Two-stream Neural Network for Anger Veracity Recognition

People can manipulate emotion expressions when interacting with others. For example, acted anger can be expressed when stimuli is not genuinely angry with an aim to manipulate the observer. In this paper, we aim to examine if the veracity of anger can be recognized with observers' pupillary data with computational approaches. We use Genetic-based Feature Selection (GFS) methods to select time-series pupillary features of of observers who observe acted and genuine anger of the video stimuli. We then use the selected features to train a simple fully connected neural work and a two-stream neural network. Our results show that the two-stream architecture is able to achieve a promising recognition result with an accuracy of 93.58% when the pupillary responses from both eyes are available. It also shows that genetic algorithm based feature selection method can effectively improve the classification accuracy by 3.07%. We hope our work could help daily research such as human machine interaction and psychology studies that require emotion recognition .