Literature-Guided Minimax Optimization of Virtual Epilepsy Neurostimulation

Computational models of epilepsy promise patient-specific treatment design, but most optimization workflows still search for parameters that perform well on average. In neuromodulation, this is a weak target: a protocol that improves the mean response can still fail in the patient whose network is least tolerant to stimulation. We present a literature-guided minimax pipeline that couples PubMed-scale hypothesis extraction, The Virtual Brain (TVB) Epileptor simulations, and large-language-model-guided black-box optimization. The optimizer proposes either intrinsic model-control parameters or clinically interpretable external-stimulation protocols; TVB evaluates each proposal across sampled virtual patients; and the objective maximizes worst-case reward, defined as the negative variance of simulated seizure activity. In the intrinsic model-control experiment, the best archived parameter set improved worst-case reward from -0.5285 to -0.3182, a 39.8% gain over baseline. The clinical-style external-stimulation search produced a much smaller worst-case improvement (1.7%), and a 20-patient virtual cohort showed no aggregate benefit (p=0.9019), despite a 55% responder rate and a positive temporal-lobe subgroup signal. The study should be read as an in silico proof of concept for robust, literature-aware neurostimulation design, not as clinical evidence.

CIVIC: End-to-End Sequence Compactness for Efficient Vision-Language Models

Vision-Language Models (VLMs) face severe memory and latency bottlenecks due to high-resolution visual tokens. While current token reduction methods theoretically save FLOPs, post-hoc pruning introduces structural overhead, failing to yield proportional wall-clock acceleration. However, enforcing a contiguous compact pathway risks geometric disorientation and loss of fine-grained localization. To overcome these barriers, this paper introduces CIVIC, a path-consistent compact visual inference framework. By maintaining compact sequence representations seamlessly across the vision encoder, projection layer, LLM prefill, and KV-cache, CIVIC avoids non-contiguous memory access and localized unmerging overheads. Evaluated on the Qwen3-VL architecture, CIVIC successfully translates sequence reductions into genuine physical hardware efficiency, shrinking KV-cache memory to approximately one-third of the baseline and reducing end-to-end inference latency. Enabled by text-aligned KL distillation and an adaptive spatial retention floor, CIVIC achieves these efficiency milestones without degrading accuracy across rigorous multimodal reasoning and visual grounding benchmarks.