MedOrchestra: A Hybrid Cloud-Local LLM Approach for Clinical Data Interpretation

Deploying large language models (LLMs) in clinical settings faces critical trade-offs: cloud LLMs, with their extensive parameters and superior performance, pose risks to sensitive clinical data privacy, while local LLMs preserve privacy but often fail at complex clinical interpretation tasks. We propose MedOrchestra, a hybrid framework where a cloud LLM decomposes complex clinical tasks into manageable subtasks and prompt generation, while a local LLM executes these subtasks in a privacy-preserving manner. Without accessing clinical data, the cloud LLM generates and validates subtask prompts using clinical guidelines and synthetic test cases. The local LLM executes subtasks locally and synthesizes outputs generated by the cloud LLM. We evaluate MedOrchestra on pancreatic cancer staging using 100 radiology reports under NCCN guidelines. On free-text reports, MedOrchestra achieves 70.21% accuracy, outperforming local model baselines (without guideline: 48.94%, with guideline: 56.59%) and board-certified clinicians (gastroenterologists: 59.57%, surgeons: 65.96%, radiologists: 55.32%). On structured reports, MedOrchestra reaches 85.42% accuracy, showing clear superiority across all settings.

HyperCLOVA X Technical Report

We introduce HyperCLOVA X, a family of large language models (LLMs) tailored to the Korean language and culture, along with competitive capabilities in English, math, and coding. HyperCLOVA X was trained on a balanced mix of Korean, English, and code data, followed by instruction-tuning with high-quality human-annotated datasets while abiding by strict safety guidelines reflecting our commitment to responsible AI. The model is evaluated across various benchmarks, including comprehensive reasoning, knowledge, commonsense, factuality, coding, math, chatting, instruction-following, and harmlessness, in both Korean and English. HyperCLOVA X exhibits strong reasoning capabilities in Korean backed by a deep understanding of the language and cultural nuances. Further analysis of the inherent bilingual nature and its extension to multilingualism highlights the model's cross-lingual proficiency and strong generalization ability to untargeted languages, including machine translation between several language pairs and cross-lingual inference tasks. We believe that HyperCLOVA X can provide helpful guidance for regions or countries in developing their sovereign LLMs.