Combining Cartesian and non-Cartesian acceleration techniques with SPARKLING for 1mm isotropic whole-brain MPRAGE in a minute

Purpose: T1-weighted MPRAGE remains a cornerstone of clinical anatomical imaging, yet its long acquisition times constrain routine use. Established acceleration techniques, namely Parallel Imaging (PI) and Compressed Sensing (CS), tend to introduce substantial noise and blurring when pushed to high acceleration factors. Although they rely on fundamentally different redundancies, combining them synergistically remains an open challenge. Methods: The GoLF-SPARKLING framework was extended to jointly exploit two acceleration mechanisms: GRAPPA-based PI in the central k-space region and variable-density CS in the periphery, with independent acceleration factors in each zone. To preserve smooth signal evolution throughout the inversion-recovery period and avoid modulation artifacts, the acquisition trajectory was reordered accordingly. The resulting method was evaluated prospectively in vivo at 1mm isotropic resolution and benchmarked against Wave-CAIPI and Poisson-disk sampling. Results: The proposed hybrid approach produced sharper, less noisy, and more stable whole-brain images in approximately one minute than either acceleration strategy alone. Purely PI-based reconstructions were degraded by high g-factor noise, while purely CS-based reconstructions exhibited pronounced blurring. Furthermore, this method yielded lower average volumetric errors in downstream automated brain segmentation than state-of-the-art acceleration techniques, demonstrating its clinical utility. Conclusion: By jointly leveraging PI and CS, GoLF-SPARKLING achieves high acceleration factors that enable sub-minute, high-quality anatomical MRI. This translates into greater clinical throughput and more reliable imaging in patients who are challenging to scan.