From Development to Deployment of AI-assisted Telehealth and Screening for Vision- and Hearing-threatening diseases in resource-constrained settings: Field Observations, Challenges and Way Forward

Vision- and hearing-threatening diseases cause preventable disability, especially in resource-constrained settings(RCS) with few specialists and limited screening setup. Large scale AI-assisted screening and telehealth has potential to expand early detection, but practical deployment is challenging in paper-based workflows and limited documented field experience exist to build upon. We provide insights on challenges and ways forward in development to adoption of scalable AI-assisted Telehealth and screening in such settings. Specifically, we find that iterative, interdisciplinary collaboration through early prototyping, shadow deployment and continuous feedback is important to build shared understanding as well as reduce usability hurdles when transitioning from paper-based to AI-ready workflows. We find public datasets and AI models highly useful despite poor performance due to domain shift. In addition, we find the need for automated AI-based image quality check to capture gradable images for robust screening in high-volume camps. Our field learning stress the importance of treating AI development and workflow digitization as an end-to-end, iterative co-design process. By documenting these practical challenges and lessons learned, we aim to address the gap in contextual, actionable field knowledge for building real-world AI-assisted telehealth and mass-screening programs in RCS.

Nearest Neighbor CCP-Based Molecular Sequence Analysis

Molecular sequence analysis is crucial for comprehending several biological processes, including protein-protein interactions, functional annotation, and disease classification. The large number of sequences and the inherently complicated nature of protein structures make it challenging to analyze such data. Finding patterns and enhancing subsequent research requires the use of dimensionality reduction and feature selection approaches. Recently, a method called Correlated Clustering and Projection (CCP) has been proposed as an effective method for biological sequencing data. The CCP technique is still costly to compute even though it is effective for sequence visualization. Furthermore, its utility for classifying molecular sequences is still uncertain. To solve these two problems, we present a Nearest Neighbor Correlated Clustering and Projection (CCP-NN)-based technique for efficiently preprocessing molecular sequence data. To group related molecular sequences and produce representative supersequences, CCP makes use of sequence-to-sequence correlations. As opposed to conventional methods, CCP doesn't rely on matrix diagonalization, therefore it can be applied to a range of machine-learning problems. We estimate the density map and compute the correlation using a nearest-neighbor search technique. We performed molecular sequence classification using CCP and CCP-NN representations to assess the efficacy of our proposed approach. Our findings show that CCP-NN considerably improves classification task accuracy as well as significantly outperforms CCP in terms of computational runtime.