DM-CFO: A Diffusion Model for Compositional 3D Tooth Generation with Collision-Free Optimization

The automatic design of a 3D tooth model plays a crucial role in dental digitization. However, current approaches face challenges in compositional 3D tooth generation because both the layouts and shapes of missing teeth need to be optimized.In addition, collision conflicts are often omitted in 3D Gaussian-based compositional 3D generation, where objects may intersect with each other due to the absence of explicit geometric information on the object surfaces. Motivated by graph generation through diffusion models and collision detection using 3D Gaussians, we propose an approach named DM-CFO for compositional tooth generation, where the layout of missing teeth is progressively restored during the denoising phase under both text and graph constraints. Then, the Gaussian parameters of each layout-guided tooth and the entire jaw are alternately updated using score distillation sampling (SDS). Furthermore, a regularization term based on the distances between the 3D Gaussians of neighboring teeth and the anchor tooth is introduced to penalize tooth intersections. Experimental results on three tooth-design datasets demonstrate that our approach significantly improves the multiview consistency and realism of the generated teeth compared with existing methods. Project page: https://amateurc.github.io/CF-3DTeeth/.

On the Automated Segmentation of Epicardial and Mediastinal Cardiac Adipose Tissues Using Classification Algorithms

The quantification of fat depots on the surroundings of the heart is an accurate procedure for evaluating health risk factors correlated with several diseases. However, this type of evaluation is not widely employed in clinical practice due to the required human workload. This work proposes a novel technique for the automatic segmentation of cardiac fat pads. The technique is based on applying classification algorithms to the segmentation of cardiac CT images. Furthermore, we extensively evaluate the performance of several algorithms on this task and discuss which provided better predictive models. Experimental results have shown that the mean accuracy for the classification of epicardial and mediastinal fats has been 98.4% with a mean true positive rate of 96.2%. On average, the Dice similarity index, regarding the segmented patients and the ground truth, was equal to 96.8%. Therfore, our technique has achieved the most accurate results for the automatic segmentation of cardiac fats, to date.

A novel approach for the automated segmentation and volume quantification of cardiac fats on computed tomography

The deposits of fat on the surroundings of the heart are correlated to several health risk factors such as atherosclerosis, carotid stiffness, coronary artery calcification, atrial fibrillation and many others. These deposits vary unrelated to obesity, which reinforces its direct segmentation for further quantification. However, manual segmentation of these fats has not been widely deployed in clinical practice due to the required human workload and consequential high cost of physicians and technicians. In this work, we propose a unified method for an autonomous segmentation and quantification of two types of cardiac fats. The segmented fats are termed epicardial and mediastinal, and stand apart from each other by the pericardium. Much effort was devoted to achieve minimal user intervention. The proposed methodology mainly comprises registration and classification algorithms to perform the desired segmentation. We compare the performance of several classification algorithms on this task, including neural networks, probabilistic models and decision tree algorithms. Experimental results of the proposed methodology have shown that the mean accuracy regarding both epicardial and mediastinal fats is 98.5% (99.5% if the features are normalized), with a mean true positive rate of 98.0%. In average, the Dice similarity index was equal to 97.6%.