Real-time Neonatal Chest Sound Separation using Deep Learning

Auscultation for neonates is a simple and non-invasive method of providing diagnosis for cardiovascular and respiratory disease. Such diagnosis often requires high-quality heart and lung sounds to be captured during auscultation. However, in most cases, obtaining such high-quality sounds is non-trivial due to the chest sounds containing a mixture of heart, lung, and noise sounds. As such, additional preprocessing is needed to separate the chest sounds into heart and lung sounds. This paper proposes a novel deep-learning approach to separate such chest sounds into heart and lung sounds. Inspired by the Conv-TasNet model, the proposed model has an encoder, decoder, and mask generator. The encoder consists of a 1D convolution model and the decoder consists of a transposed 1D convolution. The mask generator is constructed using stacked 1D convolutions and transformers. The proposed model outperforms previous methods in terms of objective distortion measures by 2.01 dB to 5.06 dB in the artificial dataset, as well as computation time, with at least a 17-time improvement. Therefore, our proposed model could be a suitable preprocessing step for any phonocardiogram-based health monitoring system.

Prediction of Neonatal Respiratory Distress in Term Babies at Birth from Digital Stethoscope Recorded Chest Sounds

Neonatal respiratory distress is a common condition that if left untreated, can lead to short- and long-term complications. This paper investigates the usage of digital stethoscope recorded chest sounds taken within 1min post-delivery, to enable early detection and prediction of neonatal respiratory distress. Fifty-one term newborns were included in this study, 9 of whom developed respiratory distress. For each newborn, 1min anterior and posterior recordings were taken. These recordings were pre-processed to remove noisy segments and obtain high-quality heart and lung sounds. The random undersampling boosting (RUSBoost) classifier was then trained on a variety of features, such as power and vital sign features extracted from the heart and lung sounds. The RUSBoost algorithm produced specificity, sensitivity, and accuracy results of 85.0%, 66.7% and 81.8%, respectively.

Noisy Neonatal Chest Sound Separation for High-Quality Heart and Lung Sounds

Stethoscope-recorded chest sounds provide the opportunity for remote cardio-respiratory health monitoring of neonates. However, reliable monitoring requires high-quality heart and lung sounds. This paper presents novel Non-negative Matrix Factorisation (NMF) and Non-negative Matrix Co-Factorisation (NMCF) methods for neonatal chest sound separation. To assess these methods and compare with existing single-source separation methods, an artificial mixture dataset was generated comprising of heart, lung and noise sounds. Signal-to-noise ratios were then calculated for these artificial mixtures. These methods were also tested on real-world noisy neonatal chest sounds and assessed based on vital sign estimation error and a signal quality score of 1-5 developed in our previous works. Additionally, the computational cost of all methods was assessed to determine the applicability for real-time processing. Overall, both the proposed NMF and NMCF methods outperform the next best existing method by 2.7dB to 11.6dB for the artificial dataset and 0.40 to 1.12 signal quality improvement for the real-world dataset. The median processing time for the sound separation of a 10s recording was found to be 28.3s for NMCF and 342ms for NMF. Because of stable and robust performance, we believe that our proposed methods are useful to denoise neonatal heart and lung sound in a real-world environment. Codes for proposed and existing methods can be found at: https://github.com/egrooby-monash/Heart-and-Lung-Sound-Separation.

Real-Time Multi-Level Neonatal Heart and Lung Sound Quality Assessment for Telehealth Applications

Digital stethoscopes in combination with telehealth allow chest sounds to be easily collected and transmitted for remote monitoring and diagnosis. Chest sounds contain important information about a newborn's cardio-respiratory health. However, low-quality recordings complicate the remote monitoring and diagnosis. In this study, a new method is proposed to objectively and automatically assess heart and lung signal quality on a 5-level scale in real-time and to assess the effect of signal quality on vital sign estimation. For the evaluation, a total of 207 10s long chest sounds were taken from 119 preterm and full-term babies. Thirty of the recordings from ten subjects were obtained with synchronous vital signs from the Neonatal Intensive Care Unit (NICU) based on electrocardiogram recordings. As reference, seven annotators independently assessed the signal quality. For automatic quality classification, 400 features were extracted from the chest sounds. After feature selection using minimum redundancy and maximum relevancy algorithm, class balancing, and hyper-parameter optimization, a variety of multi-class and ordinal classification and regression algorithms were trained. Then, heart rate and breathing rate were automatically estimated from the chest sounds using adapted pre-existing methods. The results of subject-wise leave-one-out cross-validation show that the best-performing models had a mean squared error (MSE) of 0.49 and 0.61, and balanced accuracy of 57% and 51% for heart and lung qualities, respectively. The best-performing models for real-time analysis (<200ms) had MSE of 0.459 and 0.67, and balanced accuracy of 57% and 46%, respectively. Our experimental results underscore that increasing the signal quality leads to a reduction in vital sign error, with only high-quality recordings having a mean absolute error of less than 5 beats per minute, as required for clinical usage.

A New Non-Negative Matrix Co-Factorisation Approach for Noisy Neonatal Chest Sound Separation

Obtaining high-quality heart and lung sounds enables clinicians to accurately assess a newborn's cardio-respiratory health and provide timely care. However, noisy chest sound recordings are common, hindering timely and accurate assessment. A new Non-negative Matrix Co-Factorisation-based approach is proposed to separate noisy chest sound recordings into heart, lung, and noise components to address this problem. This method is achieved through training with 20 high-quality heart and lung sounds, in parallel with separating the sounds of the noisy recording. The method was tested on 68 10-second noisy recordings containing both heart and lung sounds and compared to the current state of the art Non-negative Matrix Factorisation methods. Results show significant improvements in heart and lung sound quality scores respectively, and improved accuracy of 3.6bpm and 1.2bpm in heart and breathing rate estimation respectively, when compared to existing methods.