XAG-Net: A Cross-Slice Attention and Skip Gating Network for 2.5D Femur MRI Segmentation

Accurate segmentation of femur structures from Magnetic Resonance Imaging (MRI) is critical for orthopedic diagnosis and surgical planning but remains challenging due to the limitations of existing 2D and 3D deep learning-based segmentation approaches. In this study, we propose XAG-Net, a novel 2.5D U-Net-based architecture that incorporates pixel-wise cross-slice attention (CSA) and skip attention gating (AG) mechanisms to enhance inter-slice contextual modeling and intra-slice feature refinement. Unlike previous CSA-based models, XAG-Net applies pixel-wise softmax attention across adjacent slices at each spatial location for fine-grained inter-slice modeling. Extensive evaluations demonstrate that XAG-Net surpasses baseline 2D, 2.5D, and 3D U-Net models in femur segmentation accuracy while maintaining computational efficiency. Ablation studies further validate the critical role of the CSA and AG modules, establishing XAG-Net as a promising framework for efficient and accurate femur MRI segmentation.

Performance Analysis of Deep Learning Models for Femur Segmentation in MRI Scan

Convolutional neural networks like U-Net excel in medical image segmentation, while attention mechanisms and KAN enhance feature extraction. Meta's SAM 2 uses Vision Transformers for prompt-based segmentation without fine-tuning. However, biases in these models impact generalization with limited data. In this study, we systematically evaluate and compare the performance of three CNN-based models, i.e., U-Net, Attention U-Net, and U-KAN, and one transformer-based model, i.e., SAM 2 for segmenting femur bone structures in MRI scan. The dataset comprises 11,164 MRI scans with detailed annotations of femoral regions. Performance is assessed using the Dice Similarity Coefficient, which ranges from 0.932 to 0.954. Attention U-Net achieves the highest overall scores, while U-KAN demonstrated superior performance in anatomical regions with a smaller region of interest, leveraging its enhanced learning capacity to improve segmentation accuracy.