Can I trust my fake data -- A comprehensive quality assessment framework for synthetic tabular data in healthcare

Ensuring safe adoption of AI tools in healthcare hinges on access to sufficient data for training, testing and validation. In response to privacy concerns and regulatory requirements, using synthetic data has been suggested. Synthetic data is created by training a generator on real data to produce a dataset with similar statistical properties. Competing metrics with differing taxonomies for quality evaluation have been suggested, resulting in a complex landscape. Optimising quality entails balancing considerations that make the data fit for use, yet relevant dimensions are left out of existing frameworks. We performed a comprehensive literature review on the use of quality evaluation metrics on SD within the scope of tabular healthcare data and SD made using deep generative methods. Based on this and the collective team experiences, we developed a conceptual framework for quality assurance. The applicability was benchmarked against a practical case from the Dutch National Cancer Registry. We present a conceptual framework for quality assurance of SD for AI applications in healthcare that aligns diverging taxonomies, expands on common quality dimensions to include the dimensions of Fairness and Carbon footprint, and proposes stages necessary to support real-life applications. Building trust in synthetic data by increasing transparency and reducing the safety risk will accelerate the development and uptake of trustworthy AI tools for the benefit of patients. Despite the growing emphasis on algorithmic fairness and carbon footprint, these metrics were scarce in the literature review. The overwhelming focus was on statistical similarity using distance metrics while sequential logic detection was scarce. A consensus-backed framework that includes all relevant quality dimensions can provide assurance for safe and responsible real-life applications of SD.

Unpacking Human-AI Interaction in Safety-Critical Industries: A Systematic Literature Review

Ensuring quality human-AI interaction (HAII) in safety-critical industries is essential. Failure to do so can lead to catastrophic and deadly consequences. Despite this urgency, what little research there is on HAII is fragmented and inconsistent. We present here a survey of that literature and recommendations for research best practices that will improve the field. We divided our investigation into the following research areas: (1) terms used to describe HAII, (2) primary roles of AI-enabled systems, (3) factors that influence HAII, and (4) how HAII is measured. Additionally, we described the capabilities and maturity of the AI-enabled systems used in safety-critical industries discussed in these articles. We found that no single term is used across the literature to describe HAII and some terms have multiple meanings. According to our literature, five factors influence HAII: user characteristics and background (e.g., user personality, perceptions), AI interface and features (e.g., interactive UI design), AI output (e.g., accuracy, actionable recommendations), explainability and interpretability (e.g., level of detail, user understanding), and usage of AI (e.g., heterogeneity of environments and user needs). HAII is most commonly measured with user-related subjective metrics (e.g., user perception, trust, and attitudes), and AI-assisted decision-making is the most common primary role of AI-enabled systems. Based on this review, we conclude that there are substantial research gaps in HAII. Researchers and developers need to codify HAII terminology, involve users throughout the AI lifecycle (especially during development), and tailor HAII in safety-critical industries to the users and environments.

Doppler Spectrum Classification with CNNs via Heatmap Location Encoding and a Multi-head Output Layer

Spectral Doppler measurements are an important part of the standard echocardiographic examination. These measurements give important insight into myocardial motion and blood flow providing clinicians with parameters for diagnostic decision making. Many of these measurements can currently be performed automatically with high accuracy, increasing the efficiency of the diagnostic pipeline. However, full automation is not yet available because the user must manually select which measurement should be performed on each image. In this work we develop a convolutional neural network (CNN) to automatically classify cardiac Doppler spectra into measurement classes. We show how the multi-modal information in each spectral Doppler recording can be combined using a meta parameter post-processing mapping scheme and heatmaps to encode coordinate locations. Additionally, we experiment with several state-of-the-art network architectures to examine the tradeoff between accuracy and memory usage for resource-constrained environments. Finally, we propose a confidence metric using the values in the last fully connected layer of the network. We analyze example images that fall outside of our proposed classes to show our confidence metric can prevent many misclassifications. Our algorithm achieves 96% accuracy on a test set drawn from a separate clinical site, indicating that the proposed method is suitable for clinical adoption and enabling a fully automatic pipeline from acquisition to Doppler spectrum measurements.

User-Intended Doppler Measurement Type Prediction Combining CNNs With Smart Post-Processing

Spectral Doppler measurements are an important part of the standard echocardiographic examination. These measurements give insight into myocardial motion and blood flow providing clinicians with parameters for diagnostic decision making. Many of these measurements are performed automatically with high accuracy, increasing the efficiency of the diagnostic pipeline. However, full automation is not yet available because the user must manually select which measurement should be performed on each image. In this work, we develop a pipeline based on convolutional neural networks (CNNs) to automatically classify the measurement type from cardiac Doppler scans. We show how the multi-modal information in each spectral Doppler recording can be combined using a meta parameter post-processing mapping scheme and heatmaps to encode coordinate locations. Additionally, we experiment with several architectures to examine the tradeoff between accuracy, speed, and memory usage for resource-constrained environments. Finally, we propose a confidence metric using the values in the last fully connected layer of the network and show that our confidence metric can prevent many misclassifications. Our algorithm enables a fully automatic pipeline from acquisition to Doppler spectrum measurements. We achieve 96% accuracy on a test set drawn from a separate clinical site, indicating that the proposed method is suitable for clinical adoption.