Processing of synthetic data in AI development for healthcare and the definition of personal data in EU law

Artificial intelligence (AI) has the potential to transform healthcare, but it requires access to health data. Synthetic data that is generated through machine learning models trained on real data, offers a way to share data while preserving privacy. However, uncertainties in the practical application of the General Data Protection Regulation (GDPR) create an administrative burden, limiting the benefits of synthetic data. Through a systematic analysis of relevant legal sources and an empirical study, this article explores whether synthetic data should be classified as personal data under the GDPR. The study investigates the residual identification risk through generating synthetic data and simulating inference attacks, challenging common perceptions of technical identification risk. The findings suggest synthetic data is likely anonymous, depending on certain factors, but highlights uncertainties about what constitutes reasonably likely risk. To promote innovation, the study calls for clearer regulations to balance privacy protection with the advancement of AI in healthcare.

Permissioned Blockchain-based Framework for Ranking Synthetic Data Generators

Synthetic data generation is increasingly recognized as a crucial solution to address data related challenges such as scarcity, bias, and privacy concerns. As synthetic data proliferates, the need for a robust evaluation framework to select a synthetic data generator becomes more pressing given the variety of options available. In this research study, we investigate two primary questions: 1) How can we select the most suitable synthetic data generator from a set of options for a specific purpose? 2) How can we make the selection process more transparent, accountable, and auditable? To address these questions, we introduce a novel approach in which the proposed ranking algorithm is implemented as a smart contract within a permissioned blockchain framework called Sawtooth. Through comprehensive experiments and comparisons with state-of-the-art baseline ranking solutions, our framework demonstrates its effectiveness in providing nuanced rankings that consider both desirable and undesirable properties. Furthermore, our framework serves as a valuable tool for selecting the optimal synthetic data generators for specific needs while ensuring compliance with data protection principles.

Can I trust my fake data -- A comprehensive quality assessment framework for synthetic tabular data in healthcare

Ensuring safe adoption of AI tools in healthcare hinges on access to sufficient data for training, testing and validation. In response to privacy concerns and regulatory requirements, using synthetic data has been suggested. Synthetic data is created by training a generator on real data to produce a dataset with similar statistical properties. Competing metrics with differing taxonomies for quality evaluation have been suggested, resulting in a complex landscape. Optimising quality entails balancing considerations that make the data fit for use, yet relevant dimensions are left out of existing frameworks. We performed a comprehensive literature review on the use of quality evaluation metrics on SD within the scope of tabular healthcare data and SD made using deep generative methods. Based on this and the collective team experiences, we developed a conceptual framework for quality assurance. The applicability was benchmarked against a practical case from the Dutch National Cancer Registry. We present a conceptual framework for quality assurance of SD for AI applications in healthcare that aligns diverging taxonomies, expands on common quality dimensions to include the dimensions of Fairness and Carbon footprint, and proposes stages necessary to support real-life applications. Building trust in synthetic data by increasing transparency and reducing the safety risk will accelerate the development and uptake of trustworthy AI tools for the benefit of patients. Despite the growing emphasis on algorithmic fairness and carbon footprint, these metrics were scarce in the literature review. The overwhelming focus was on statistical similarity using distance metrics while sequential logic detection was scarce. A consensus-backed framework that includes all relevant quality dimensions can provide assurance for safe and responsible real-life applications of SD.