Decoder-Free Supervoxel GNN for Accurate Brain-Tumor Localization in Multi-Modal MRI

Modern vision backbones for 3D medical imaging typically process dense voxel grids through parameter-heavy encoder-decoder structures, a design that allocates a significant portion of its parameters to spatial reconstruction rather than feature learning. Our approach introduces SVGFormer, a decoder-free pipeline built upon a content-aware grouping stage that partitions the volume into a semantic graph of supervoxels. Its hierarchical encoder learns rich node representations by combining a patch-level Transformer with a supervoxel-level Graph Attention Network, jointly modeling fine-grained intra-region features and broader inter-regional dependencies. This design concentrates all learnable capacity on feature encoding and provides inherent, dual-scale explainability from the patch to the region level. To validate the framework's flexibility, we trained two specialized models on the BraTS dataset: one for node-level classification and one for tumor proportion regression. Both models achieved strong performance, with the classification model achieving a F1-score of 0.875 and the regression model a MAE of 0.028, confirming the encoder's ability to learn discriminative and localized features. Our results establish that a graph-based, encoder-only paradigm offers an accurate and inherently interpretable alternative for 3D medical image representation.

Federated GNNs for EEG-Based Stroke Assessment

Machine learning (ML) has the potential to become an essential tool in supporting clinical decision-making processes, offering enhanced diagnostic capabilities and personalized treatment plans. However, outsourcing medical records to train ML models using patient data raises legal, privacy, and security concerns. Federated learning has emerged as a promising paradigm for collaborative ML, meeting healthcare institutions' requirements for robust models without sharing sensitive data and compromising patient privacy. This study proposes a novel method that combines federated learning (FL) and Graph Neural Networks (GNNs) to predict stroke severity using electroencephalography (EEG) signals across multiple medical institutions. Our approach enables multiple hospitals to jointly train a shared GNN model on their local EEG data without exchanging patient information. Specifically, we address a regression problem by predicting the National Institutes of Health Stroke Scale (NIHSS), a key indicator of stroke severity. The proposed model leverages a masked self-attention mechanism to capture salient brain connectivity patterns and employs EdgeSHAP to provide post-hoc explanations of the neurological states after a stroke. We evaluated our method on EEG recordings from four institutions, achieving a mean absolute error (MAE) of 3.23 in predicting NIHSS, close to the average error made by human experts (MAE $\approx$ 3.0). This demonstrates the method's effectiveness in providing accurate and explainable predictions while maintaining data privacy.

A Secure and Trustworthy Network Architecture for Federated Learning Healthcare Applications

Federated Learning (FL) has emerged as a promising approach for privacy-preserving machine learning, particularly in sensitive domains such as healthcare. In this context, the TRUSTroke project aims to leverage FL to assist clinicians in ischemic stroke prediction. This paper provides an overview of the TRUSTroke FL network infrastructure. The proposed architecture adopts a client-server model with a central Parameter Server (PS). We introduce a Docker-based design for the client nodes, offering a flexible solution for implementing FL processes in clinical settings. The impact of different communication protocols (HTTP or MQTT) on FL network operation is analyzed, with MQTT selected for its suitability in FL scenarios. A control plane to support the main operations required by FL processes is also proposed. The paper concludes with an analysis of security aspects of the FL architecture, addressing potential threats and proposing mitigation strategies to increase the trustworthiness level.