The Potential and Pitfalls of using a Large Language Model such as ChatGPT or GPT-4 as a Clinical Assistant

Recent studies have demonstrated promising performance of ChatGPT and GPT-4 on several medical domain tasks. However, none have assessed its performance using a large-scale real-world electronic health record database, nor have evaluated its utility in providing clinical diagnostic assistance for patients across a full range of disease presentation. We performed two analyses using ChatGPT and GPT-4, one to identify patients with specific medical diagnoses using a real-world large electronic health record database and the other, in providing diagnostic assistance to healthcare workers in the prospective evaluation of hypothetical patients. Our results show that GPT-4 across disease classification tasks with chain of thought and few-shot prompting can achieve performance as high as 96% F1 scores. For patient assessment, GPT-4 can accurately diagnose three out of four times. However, there were mentions of factually incorrect statements, overlooking crucial medical findings, recommendations for unnecessary investigations and overtreatment. These issues coupled with privacy concerns, make these models currently inadequate for real world clinical use. However, limited data and time needed for prompt engineering in comparison to configuration of conventional machine learning workflows highlight their potential for scalability across healthcare applications.

Predicting Model Failure using Saliency Maps in Autonomous Driving Systems

While machine learning systems show high success rate in many complex tasks, research shows they can also fail in very unexpected situations. Rise of machine learning products in safety-critical industries cause an increase in attention in evaluating model robustness and estimating failure probability in machine learning systems. In this work, we propose a design to train a student model -- a failure predictor -- to predict the main model's error for input instances based on their saliency map. We implement and review the preliminary results of our failure predictor model on an autonomous vehicle steering control system as an example of safety-critical applications.