In this paper, we propose time and frequency synchronization techniques for uplink multiuser OTFS (MU-OTFS) systems in high-mobility scenarios. This work focuses on accurately estimating and correcting timing offsets (TOs) and carrier frequency offsets (CFOs). Specifically, TO estimation is essential for locating users' pilots on the delay-time plane, while CFO estimation enhances channel estimation accuracy. First, we propose a TO estimation technique for an existing multiuser pilot structure in MU-OTFS. We replace the impulse pilot (IMP) in this pilot structure with a more practical pilot with a cyclic prefix (PCP), referred to as single-user-inspired PCP (SU-PCP). This structure employs different Zadoff-Chu (ZC) sequences, which enables pilot separation via correlation at the receiver side. Consequently, we introduce a correlation-based TO estimation technique for uplink MU-OTFS using this pilot structure. Next, a spectrally efficient and practical pilot pattern is proposed, where each user transmits a PCP within a shared pilot region on the delay-Doppler plane, referred to as MU-PCP. At the receiver, the second TO estimation technique utilizes a bank of filters to separate different users' signals and accurately estimate their TOs. Then, we derive a mathematical threshold range to enhance TO estimation accuracy by finding the first major peak in the correlation function rather than relying solely on the highest peak. After locating the received users' pilot signals using one of the proposed TO estimation techniques, our proposed CFO estimation technique reduces the multi-dimensional maximum likelihood (ML) search problem into multiple one-dimensional search problems. In this technique, we apply the Chebyshev polynomials of the first kind basis expansion model (CPF-BEM) to effectively handle the time-variations of the channel in obtaining the CFO estimates for all the users.