Recent advances in robotics have enabled the widespread deployment of autonomous robotic systems in complex operational environments, presenting both unprecedented opportunities and significant security problems. Traditional shepherding approaches based on fixed formations are often ineffective or risky in urban and obstacle-rich scenarios, especially when facing adversarial agents with unknown and adaptive behaviors. This paper addresses this challenge as an extended herding problem, where defensive robotic systems must safely guide adversarial agents with unknown strategies away from protected areas and into predetermined safe regions, while maintaining collision-free navigation in dynamic environments. We propose a hierarchical hybrid framework based on reach-avoid game theory and local motion planning, incorporating a virtual containment boundary and event-triggered pursuit mechanisms to enable scalable and robust multi-agent coordination. Simulation results demonstrate that the proposed approach achieves safe and efficient guidance of adversarial agents to designated regions.