Dual-Attention Frequency Fusion at Multi-Scale for Joint Segmentation and Deformable Medical Image Registration

Deformable medical image registration is a crucial aspect of medical image analysis. In recent years, researchers have begun leveraging auxiliary tasks (such as supervised segmentation) to provide anatomical structure information for the primary registration task, addressing complex deformation challenges in medical image registration. In this work, we propose a multi-task learning framework based on multi-scale dual attention frequency fusion (DAFF-Net), which simultaneously achieves the segmentation masks and dense deformation fields in a single-step estimation. DAFF-Net consists of a global encoder, a segmentation decoder, and a coarse-to-fine pyramid registration decoder. During the registration decoding process, we design the dual attention frequency feature fusion (DAFF) module to fuse registration and segmentation features at different scales, fully leveraging the correlation between the two tasks. The DAFF module optimizes the features through global and local weighting mechanisms. During local weighting, it incorporates both high-frequency and low-frequency information to further capture the features that are critical for the registration task. With the aid of segmentation, the registration learns more precise anatomical structure information, thereby enhancing the anatomical consistency of the warped images after registration. Additionally, due to the DAFF module's outstanding ability to extract effective feature information, we extend its application to unsupervised registration. Extensive experiments on three public 3D brain magnetic resonance imaging (MRI) datasets demonstrate that the proposed DAFF-Net and its unsupervised variant outperform state-of-the-art registration methods across several evaluation metrics, demonstrating the effectiveness of our approach in deformable medical image registration.