Detecting Structural Heart Disease from Electrocardiograms via a Generalized Additive Model of Interpretable Foundation-Model Predictors

Structural heart disease (SHD) is a prevalent condition with many undiagnosed cases, and early detection is often limited by the high cost and accessibility constraints of echocardiography (ECHO). Recent studies show that artificial intelligence (AI)-based analysis of electrocardiograms (ECGs) can detect SHD, offering a scalable alternative. However, existing methods are fully black-box models, limiting interpretability and clinical adoption. To address these challenges, we propose an interpretable and effective framework that integrates clinically meaningful ECG foundation-model predictors within a generalized additive model, enabling transparent risk attribution while maintaining strong predictive performance. Using the EchoNext benchmark of over 80,000 ECG-ECHO pairs, the method demonstrates relative improvements of +0.98% in AUROC, +1.01% in AUPRC, and +1.41% in F1 score over the latest state-of-the-art deep-learning baseline, while achieving slightly better performance even with only 30% of the training data. Subgroup analyses confirm robust performance across heterogeneous populations, and the estimated entry-wise functions provide interpretable insights into the relationships between risks of traditional ECG diagnoses and SHD. This work illustrates a complementary paradigm between classical statistical modeling and modern AI, offering a pathway to interpretable, high-performing, and clinically actionable ECG-based SHD screening.

From Matching with Diversity Constraints to Matching with Regional Quotas

In the past few years, several new matching models have been proposed and studied that take into account complex distributional constraints. Relevant lines of work include (1) school choice with diversity constraints where students have (possibly overlapping) types and (2) hospital-doctor matching where various regional quotas are imposed. In this paper, we present a polynomial-time reduction to transform an instance of (1) to an instance of (2) and we show how the feasibility and stability of corresponding matchings are preserved under the reduction. Our reduction provides a formal connection between two important strands of work on matching with distributional constraints. We then apply the reduction in two ways. Firstly, we show that it is NP-complete to check whether a feasible and stable outcome for (1) exists. Due to our reduction, these NP-completeness results carry over to setting (2). In view of this, we help unify some of the results that have been presented in the literature. Secondly, if we have positive results for (2), then we have corresponding results for (1). One key conclusion of our results is that further developments on axiomatic and algorithmic aspects of hospital-doctor matching with regional quotas will result in corresponding results for school choice with diversity constraints.