Multimodal Model for Computational Pathology:Representation Learning and Image Compression

Whole slide imaging (WSI) has transformed digital pathology by enabling computational analysis of gigapixel histopathology images. Recent foundation model advances have accelerated progress in computational pathology, facilitating joint reasoning across pathology images, clinical reports, and structured data. Despite this progress, challenges remain: the extreme resolution of WSIs creates computational hurdles for visual learning; limited expert annotations constrain supervised approaches; integrating multimodal information while preserving biological interpretability remains difficult; and the opacity of modeling ultra-long visual sequences hinders clinical transparency. This review comprehensively surveys recent advances in multimodal computational pathology. We systematically analyze four research directions: (1) self-supervised representation learning and structure-aware token compression for WSIs; (2) multimodal data generation and augmentation; (3) parameter-efficient adaptation and reasoning-enhanced few-shot learning; and (4) multi-agent collaborative reasoning for trustworthy diagnosis. We specifically examine how token compression enables cross-scale modeling and how multi-agent mechanisms simulate a pathologist's "Chain of Thought" across magnifications to achieve uncertainty-aware evidence fusion. Finally, we discuss open challenges and argue that future progress depends on unified multimodal frameworks integrating high-resolution visual data with clinical and biomedical knowledge to support interpretable and safe AI-assisted diagnosis.

ZeroSense:How Vision matters in Long Context Compression

Recent visual-text compression (VTC) methods, typified by DeepSeek-OCR, report impressive high token compression ratios for long-context modeling tasks by leveraging text-to-image rendering. However, existing evaluation protocols heavily rely on downstream task performance. Such evaluation metrics fail to accurately measure text preservation due to the strong inherent linguistic priors of Multimodal Large Language Models (MLLMs). In this work, we introduce a new evaluation framework that decouples MLLMs' capabilities to faithfully assess VTC quality. Within this framework, we further introduce the ZeroSense Benchmark to ensure low semantic correlation of testing samples. By eliminating contextual dependencies, our benchmark guarantees that the evaluation results are purely reflective of VTC quality, unaffected by the semantic inference capabilities of downstream models. Extensive experiments across multiple datasets demonstrate that VTC quality and downstream task accuracy diverge significantly, highlighting the necessity of our decoupled evaluation framework.