Synthesizing Individualized Aging Brains in Health and Disease with Generative Models and Parallel Transport

Simulating prospective magnetic resonance imaging (MRI) scans from a given individual brain image is challenging, as it requires accounting for canonical changes in aging and/or disease progression while also considering the individual brain's current status and unique characteristics. While current deep generative models can produce high-resolution anatomically accurate templates for population-wide studies, their ability to predict future aging trajectories for individuals remains limited, particularly in capturing subject-specific neuroanatomical variations over time. In this study, we introduce Individualized Brain Synthesis (InBrainSyn), a framework for synthesizing high-resolution subject-specific longitudinal MRI scans that simulate neurodegeneration in both Alzheimer's disease (AD) and normal aging. InBrainSyn uses a parallel transport algorithm to adapt the population-level aging trajectories learned by a generative deep template network, enabling individualized aging synthesis. As InBrainSyn uses diffeomorphic transformations to simulate aging, the synthesized images are topologically consistent with the original anatomy by design. We evaluated InBrainSyn both quantitatively and qualitatively on AD and healthy control cohorts from the Open Access Series of Imaging Studies - version 3 dataset. Experimentally, InBrainSyn can also model neuroanatomical transitions between normal aging and AD. An evaluation of an external set supports its generalizability. Overall, with only a single baseline scan, InBrainSyn synthesizes realistic 3D spatiotemporal T1w MRI scans, producing personalized longitudinal aging trajectories. The code for InBrainSyn is available at: https://github.com/Fjr9516/InBrainSyn.

Adaptive Kalman-based hybrid car following strategy using TD3 and CACC

In autonomous driving, the hybrid strategy of deep reinforcement learning and cooperative adaptive cruise control (CACC) can fully utilize the advantages of the two algorithms and significantly improve the performance of car following. However, it is challenging for the traditional hybrid strategy based on fixed coefficients to adapt to mixed traffic flow scenarios, which may decrease the performance and even lead to accidents. To address the above problems, a hybrid car following strategy based on an adaptive Kalman Filter is proposed by regarding CACC and Twin Delayed Deep Deterministic Policy Gradient (TD3) algorithms. Different from traditional hybrid strategy based on fixed coefficients, the Kalman gain H, using as an adaptive coefficient, is derived from multi-timestep predictions and Monte Carlo Tree Search. At the end of study, simulation results with 4157745 timesteps indicate that, compared with the TD3 and HCFS algorithms, the proposed algorithm in this study can substantially enhance the safety of car following in mixed traffic flow without compromising the comfort and efficiency.