LT-Mem: Volatility-Aware Spatio-Temporal Memory for Lifelong Scene Understanding

Long-term robot operation in evolving environments requires object-level understanding that persists across repeated revisits. Existing systems either overwrite history to maintain an up-to-date map or store semantic snapshots without consistent cross-session object identity, resulting in temporal amnesia: the systematic loss of object history that prevents answering queries such as "Where has the green chair been across all sessions?" We propose LT-Mem, a volatility-aware memory evolution framework that unifies spatially aligned instance-level 3D perception with volatility-conditioned temporal reasoning. First, a multi-session SLAM backbone provides spatially aligned per-object observations across sessions. Second, a reasoning layer governs how object memory evolves: deterministic evidence scoring preserves cross-session identity, and a volatility-aware policy selects among overwrite, hold, and multi-hypothesis actions based on each object's dynamics. Third, the resulting Tri-Memory structure (Live, Delta, Meta) preserves both current states and event histories, enabling longitudinal object-centric reasoning. We further introduce LT-VQA, a dataset and evaluation suite comprising multi-session recordings, persistent identity annotations, and temporal QA pairs. Experiments show that LT-Mem consistently outperforms baselines across all metrics while consuming an order of magnitude fewer tokens, and ablations confirm that gains are driven by the structured memory architecture rather than LLM capacity.

Spatial proteomics guided by H&E-based AI reveals recurrence-risk niches in triple-negative breast cancer

Deep learning models can predict cancer recurrence from H&E stained slides, but the localized molecular states underlying these predictions remain largely obscured. Here, we developed an outcome informed spatial pathology framework in TNBC that integrates AI generated recurrence risk heatmaps with mass spectrometry based spatial proteomics. In a cohort of 156 patients, distribution based aggregation of high scoring patches achieved an AUC of 0.77 and a C-index of 0.77 in an independent test cohort. Bulk proteomics associated high image derived risk with cell cycle and genome maintenance programs and low risk with immune activation. High and low risk patches coexisted within the same tumor compartment and displayed distinct nuclear and architectural features, revealing intratumoral heterogeneity beyond tissue compartment identity. We then used the heatmaps as coordinate level guides to physically isolate and profile 46 AI defined tumor regions from two recurrence patients. Spatial proteomic profiling revealed a concordant molecular contrast across both patients: mitotic programs were enriched in high risk regions and immune and antigen presentation programs in low risk regions. A 13 protein composite derived from these spatial contrasts showed a trend toward poorer recurrence-free survival with increasing scores in an expanded cohort, while the corresponding transcript based composite stratified recurrence free survival in the independent METABRIC TNBC cohort. Integrating the protein composite with the H&E derived risk score improved the out of bag C-index from 0.679 to 0.739 and enhanced time dependent discrimination at 3 and 5 years. Together, these findings define a new role for outcome trained AI models as spatially explicit experimental guides that connect prognostic morphology with localized molecular states and advance biologically grounded, multiscale biomarker discovery in TNBC.

ReFEree: Reference-Free and Fine-Grained Method for Evaluating Factual Consistency in Real-World Code Summarization

As Large Language Models (LLMs) have become capable of generating long and descriptive code summaries, accurate and reliable evaluation of factual consistency has become a critical challenge. However, previous evaluation methods are primarily designed for short summaries of isolated code snippets. Consequently, they struggle to provide fine-grained evaluation of multi-sentence functionalities and fail to accurately assess dependency context commonly found in real-world code summaries. To address this, we propose ReFEree, a reference-free and fine-grained method for evaluating factual consistency in real-world code summaries. We define factual inconsistency criteria specific to code summaries and evaluate them at the segment level using these criteria along with dependency information. These segment-level results are then aggregated into a fine-grained score. We construct a code summarization benchmark with human-annotated factual consistency labels. The evaluation results demonstrate that ReFEree achieves the highest correlation with human judgment among 13 baselines, improving 15-18% over the previous state-of-the-art. Our code and data are available at https://github.com/bsy99615/ReFEree.git.

MEDFORD in a Box: Improvements and Future Directions for a Metadata Description Language

Scientific research metadata is vital to ensure the validity, reusability, and cost-effectiveness of research efforts. The MEDFORD metadata language was previously introduced to simplify the process of writing and maintaining metadata for non-programmers. However, barriers to entry and usability remain, including limited automatic validation, difficulty of data transport, and user unfamiliarity with text file editing. To address these issues, we introduce MEDFORD-in-a-Box (MIAB), a documentation ecosystem to facilitate researcher adoption and earlier metadata capture. MIAB contains many improvements, including an updated MEDFORD parser with expanded validation routines and BagIt export capability. MIAB also includes an improved VS Code extension that supports these changes through a visual IDE. By simplifying metadata generation, this new tool supports the creation of correct, consistent, and reusable metadata, ultimately improving research reproducibility.

Sparse Bayesian Message Passing under Structural Uncertainty

Semi-supervised learning on real-world graphs is frequently challenged by heterophily, where the observed graph is unreliable or label-disassortative. Many existing graph neural networks either rely on a fixed adjacency structure or attempt to handle structural noise through regularization. In this work, we explicitly capture structural uncertainty by modeling a posterior distribution over signed adjacency matrices, allowing each edge to be positive, negative, or absent. We propose a sparse signed message passing network that is naturally robust to edge noise and heterophily, which can be interpreted from a Bayesian perspective. By combining (i) posterior marginalization over signed graph structures with (ii) sparse signed message aggregation, our approach offers a principled way to handle both edge noise and heterophily. Experimental results demonstrate that our method outperforms strong baseline models on heterophilic benchmarks under both synthetic and real-world structural noise.