PerturbPFN: Probing the Limits of Synthetic Priors in Drug Perturbation Modelling

Predicting cellular responses to unseen chemical perturbations is challenging due to unknown targets and mechanisms, high-dimensional expression responses, and limited experimental coverage of the large small-molecule design space. We propose PerturbPFN, a PFN-style amortized model for unknown-target perturbation prediction under a hierarchical synthetic structural prior. Instead of directly regressing high-dimensional expression responses, PerturbPFN infers a latent system graph, sparse atomic intervention targets, and intervention strengths, then propagates their effects through an SCM decoder. The model is trained entirely on prior-predictive synthetic episodes generated from biologically motivated graph and expression simulators, enabling structured in-context learning without test-time gradient updates. We evaluate PerturbPFN on both real single-cell perturbation data and synthetic benchmarks, covering effect prediction, target identification, and regulatory structure discovery. Our results show that PerturbPFN offers a complementary trade-off to specialized baselines, achieving competitive perturbation prediction with low inference cost while exposing interpretable intermediate estimates of targets, strengths, and system structure.

Semantics-Driven Cloud-Edge Collaborative Inference

With the proliferation of video data in smart city applications like intelligent transportation, efficient video analytics has become crucial but also challenging. This paper proposes a semantics-driven cloud-edge collaborative approach for accelerating video inference, using license plate recognition as a case study. The method separates semantics extraction and recognition, allowing edge servers to only extract visual semantics (license plate patches) from video frames and offload computation-intensive recognition to the cloud or neighboring edges based on load. This segmented processing coupled with a load-aware work distribution strategy aims to reduce end-to-end latency and improve throughput. Experiments demonstrate significant improvements in end-to-end inference speed (up to 5x faster), throughput (up to 9 FPS), and reduced traffic volumes (50% less) compared to cloud-only or edge-only processing, validating the efficiency of the proposed approach. The cloud-edge collaborative framework with semantics-driven work partitioning provides a promising solution for scaling video analytics in smart cities.