Balancing Common Treatment and Epidemic Control in Medical Procurement during COVID-19: Transform-and-Divide Evolutionary Optimization

Balancing common disease treatment and epidemic control is a key objective of medical supplies procurement in hospitals during a pandemic such as COVID-19. This problem can be formulated as a bi-objective optimization problem for simultaneously optimizing the effects of common disease treatment and epidemic control. However, due to the large number of supplies, difficulties in evaluating the effects, and the strict budget constraint, it is difficult for existing evolutionary multiobjective algorithms to efficiently approximate the Pareto front of the problem. In this paper, we present an approach that first transforms the original high-dimensional, constrained multiobjective optimization problem to a low-dimensional, unconstrained multiobjective optimization problem, and then evaluates each solution to the transformed problem by solving a set of simple single-objective optimization subproblems, such that the problem can be efficiently solved by existing evolutionary multiobjective algorithms. We applied the transform-and-divide evolutionary optimization approach to six hospitals in Zhejiang Province, China, during the peak of COVID-19. Results showed that the proposed approach exhibits significantly better performance than that of directly solving the original problem. Our study has also shown that transform-and-divide evolutionary optimization based on problem-specific knowledge can be an efficient solution approach to many other complex problems and, therefore, enlarge the application field of evolutionary algorithms.

Real-Time Neural Network Scheduling of Emergency Medical Mask Production during COVID-19

During the outbreak of the novel coronavirus pneumonia (COVID-19), there is a huge demand for medical masks. A mask manufacturer often receives a large amount of orders that are beyond its capability. Therefore, it is of critical importance for the manufacturer to schedule mask production tasks as efficiently as possible. However, existing scheduling methods typically require a considerable amount of computational resources and, therefore, cannot effectively cope with the surge of orders. In this paper, we propose an end-to-end neural network for scheduling real-time production tasks. The neural network takes a sequence of production tasks as inputs to predict a distribution over different schedules, employs reinforcement learning to optimize network parameters using the negative total tardiness as the reward signal, and finally produces a high-quality solution to the scheduling problem. We applied the proposed approach to schedule emergency production tasks for a medical mask manufacturer during the peak of COVID-19 in China. Computational results show that the neural network scheduler can solve problem instances with hundreds of tasks within seconds. The objective function value (i.e., the total weighted tardiness) produced by the neural network scheduler is significantly better than those of existing constructive heuristics, and is very close to those of the state-of-the-art metaheuristics whose computational time is unaffordable in practice.

Intelligent Optimization of Diversified Community Prevention of COVID-19 using Traditional Chinese Medicine

Traditional Chinese medicine (TCM) has played an important role in the prevention and control of the novel coronavirus pneumonia (COVID-19), and community prevention has become the most essential part in reducing the spread risk and protecting populations. However, most communities use a uniform TCM prevention program for all residents, which violates the "treatment based on syndrome differentiation" principle of TCM and limits the effectiveness of prevention. In this paper, we propose an intelligent optimization method to develop diversified TCM prevention programs for community residents. First, we use a fuzzy clustering method to divide the population based on both modern medicine and TCM health characteristics; we then use an interactive optimization method, in which TCM experts develop different TCM prevention programs for different clusters, and a heuristic algorithm is used to optimize the programs under the resource constraints. We demonstrate the computational efficiency of the proposed method and report its successful application to TCM-based prevention of COVID-19 in 12 communities in Zhejiang province, China, during the peak of the pandemic.