GROVER: Graph-guided Representation of Omics and Vision with Expert Regulation for Adaptive Spatial Multi-omics Fusion

Effectively modeling multimodal spatial omics data is critical for understanding tissue complexity and underlying biological mechanisms. While spatial transcriptomics, proteomics, and epigenomics capture molecular features, they lack pathological morphological context. Integrating these omics with histopathological images is therefore essential for comprehensive disease tissue analysis. However, substantial heterogeneity across omics, imaging, and spatial modalities poses significant challenges. Naive fusion of semantically distinct sources often leads to ambiguous representations. Additionally, the resolution mismatch between high-resolution histology images and lower-resolution sequencing spots complicates spatial alignment. Biological perturbations during sample preparation further distort modality-specific signals, hindering accurate integration. To address these challenges, we propose Graph-guided Representation of Omics and Vision with Expert Regulation for Adaptive Spatial Multi-omics Fusion (GROVER), a novel framework for adaptive integration of spatial multi-omics data. GROVER leverages a Graph Convolutional Network encoder based on Kolmogorov-Arnold Networks to capture the nonlinear dependencies between each modality and its associated spatial structure, thereby producing expressive, modality-specific embeddings. To align these representations, we introduce a spot-feature-pair contrastive learning strategy that explicitly optimizes the correspondence across modalities at each spot. Furthermore, we design a dynamic expert routing mechanism that adaptively selects informative modalities for each spot while suppressing noisy or low-quality inputs. Experiments on real-world spatial omics datasets demonstrate that GROVER outperforms state-of-the-art baselines, providing a robust and reliable solution for multimodal integration.

Multi-Bit Mechanism: A Novel Information Transmission Paradigm for Spiking Neural Networks

Since proposed, spiking neural networks (SNNs) gain recognition for their high performance, low power consumption and enhanced biological interpretability. However, while bringing these advantages, the binary nature of spikes also leads to considerable information loss in SNNs, ultimately causing performance degradation. We claim that the limited expressiveness of current binary spikes, resulting in substantial information loss, is the fundamental issue behind these challenges. To alleviate this, our research introduces a multi-bit information transmission mechanism for SNNs. This mechanism expands the output of spiking neurons from the original single bit to multiple bits, enhancing the expressiveness of the spikes and reducing information loss during the forward process, while still maintaining the low energy consumption advantage of SNNs. For SNNs, this represents a new paradigm of information transmission. Moreover, to further utilize the limited spikes, we extract effective signals from the previous layer to re-stimulate the neurons, thus encouraging full spikes emission across various bit levels. We conducted extensive experiments with our proposed method using both direct training method and ANN-SNN conversion method, and the results show consistent performance improvements.

Shrinking Your TimeStep: Towards Low-Latency Neuromorphic Object Recognition with Spiking Neural Network

Neuromorphic object recognition with spiking neural networks (SNNs) is the cornerstone of low-power neuromorphic computing. However, existing SNNs suffer from significant latency, utilizing 10 to 40 timesteps or more, to recognize neuromorphic objects. At low latencies, the performance of existing SNNs is drastically degraded. In this work, we propose the Shrinking SNN (SSNN) to achieve low-latency neuromorphic object recognition without reducing performance. Concretely, we alleviate the temporal redundancy in SNNs by dividing SNNs into multiple stages with progressively shrinking timesteps, which significantly reduces the inference latency. During timestep shrinkage, the temporal transformer smoothly transforms the temporal scale and preserves the information maximally. Moreover, we add multiple early classifiers to the SNN during training to mitigate the mismatch between the surrogate gradient and the true gradient, as well as the gradient vanishing/exploding, thus eliminating the performance degradation at low latency. Extensive experiments on neuromorphic datasets, CIFAR10-DVS, N-Caltech101, and DVS-Gesture have revealed that SSNN is able to improve the baseline accuracy by 6.55% ~ 21.41%. With only 5 average timesteps and without any data augmentation, SSNN is able to achieve an accuracy of 73.63% on CIFAR10-DVS. This work presents a heterogeneous temporal scale SNN and provides valuable insights into the development of high-performance, low-latency SNNs.