Heterogeneous Neural Predictivity from Language Models During Naturalistic Comprehension

Language-model representations provide structured, high-dimensional annotations of naturalistic language stimuli and can serve as informative neural predictors during comprehension. We analyzed locked derived data from Brain Treebank, MEG-MASC, and Podcast ECoG with eight frozen language models, blocked encoding models, and matched temporal, nuisance, and representation-capacity controls. Positive held-out prediction and gains over low-level baselines were widespread in source-level summaries. Across Brain Treebank and Podcast ECoG, 67 of 432 evaluable rows met a controlled predictive-only criterion, and model-side feature ablations changed prediction scores in most evaluable source rows. Brain-derived, timing-linked, acoustic, and implanted-signal controls confirmed component-level sensitivity of the analysis pipeline. These findings show that language-model-derived quantities can annotate neural activity during natural speech and text comprehension. Participant-level matched-control advantages were localized rather than uniform, response-profile and feature-specificity contrasts bounded representational or computational interpretations, and complete co-indexed integrated interpretation will require future jointly indexed coverage. Together, the analyses identify language-model features as useful neural predictors and separate predictive usefulness from claims about shared neural organization or language-processing computations.

Do Language Models Align with Brains? Prediction Scores Are Not Enough

Brain-language model comparisons often interpret neural prediction scores as evidence that model representations capture brain-relevant language computation. We asked whether language models align with brains, and whether prediction scores are enough to support that claim, using L-PACT, a source-audited framework that evaluates predictive, relational, mechanism-stripping, and reliability-bounded evidence. Across primary naturalistic language neural datasets and derived language-model representations, L-PACT compared real model features with nuisance baselines and severe controls, tested whether model-to-brain profiles reproduced brain-to-brain patterns, recomputed held-out scores after mechanism stripping, and normalized evidence against brain-brain ceilings. The locked analysis set contains 414 predictive-control rows, 2304 relational profile rows, 4320 mechanism-stripping rows, 420 brain-brain ceiling rows, and 146 integrated decision rows. Assay-sensitivity checks showed that brain-brain reliability, brain-as-model run-to-run relational profiles, independent low-level neural and WAV-derived acoustic-envelope gates, and a deterministic implanted-signal simulation can produce positive evidence when expected. Nevertheless, no real model row passed the predictive, relational, mechanism-stripping, or operational Turing-bounded reliability gates; all 146 integrated rows were control-explained. Less stringent single-criterion rules would have counted raw positive predictive, relational, stripping-delta, and ceiling-normalized effects, but L-PACT downgraded them because controls explained the apparent evidence. In the analyzed derived artifact set, the tested language-model representations do not satisfy L-PACT alignment gates; apparent positives are converted into an auditable control-explained taxonomy rather than treated as structural alignment.

The Emergence of Altruism in Large-Language-Model Agents Society

Leveraging Large Language Models (LLMs) for social simulation is a frontier in computational social science. Understanding the social logics these agents embody is critical to this attempt. However, existing research has primarily focused on cooperation in small-scale, task-oriented games, overlooking how altruism, which means sacrificing self-interest for collective benefit, emerges in large-scale agent societies. To address this gap, we introduce a Schelling-variant urban migration model that creates a social dilemma, compelling over 200 LLM agents to navigate an explicit conflict between egoistic (personal utility) and altruistic (system utility) goals. Our central finding is a fundamental difference in the social tendencies of LLMs. We identify two distinct archetypes: "Adaptive Egoists", which default to prioritizing self-interest but whose altruistic behaviors significantly increase under the influence of a social norm-setting message board; and "Altruistic Optimizers", which exhibit an inherent altruistic logic, consistently prioritizing collective benefit even at a direct cost to themselves. Furthermore, to qualitatively analyze the cognitive underpinnings of these decisions, we introduce a method inspired by Grounded Theory to systematically code agent reasoning. In summary, this research provides the first evidence of intrinsic heterogeneity in the egoistic and altruistic tendencies of different LLMs. We propose that for social simulation, model selection is not merely a matter of choosing reasoning capability, but of choosing an intrinsic social action logic. While "Adaptive Egoists" may offer a more suitable choice for simulating complex human societies, "Altruistic Optimizers" are better suited for modeling idealized pro-social actors or scenarios where collective welfare is the primary consideration.

Machine Learning Techniques for Biomedical Image Segmentation: An Overview of Technical Aspects and Introduction to State-of-Art Applications

In recent years, significant progress has been made in developing more accurate and efficient machine learning algorithms for segmentation of medical and natural images. In this review article, we highlight the imperative role of machine learning algorithms in enabling efficient and accurate segmentation in the field of medical imaging. We specifically focus on several key studies pertaining to the application of machine learning methods to biomedical image segmentation. We review classical machine learning algorithms such as Markov random fields, k-means clustering, random forest, etc. Although such classical learning models are often less accurate compared to the deep learning techniques, they are often more sample efficient and have a less complex structure. We also review different deep learning architectures, such as the artificial neural networks (ANNs), the convolutional neural networks (CNNs), and the recurrent neural networks (RNNs), and present the segmentation results attained by those learning models that were published in the past three years. We highlight the successes and limitations of each machine learning paradigm. In addition, we discuss several challenges related to the training of different machine learning models, and we present some heuristics to address those challenges.