Abstract:Preparing high-quality instructional materials remains a labor-intensive process that often requires extensive coordination among teaching faculty, instructional designers, and teaching assistants. In this work, we present Instructional Agents, a multi-agent large language model (LLM) framework designed to automate end-to-end course material generation, including syllabus creation, lecture scripts, LaTeX-based slides, and assessments. Unlike existing AI-assisted educational tools that focus on isolated tasks, Instructional Agents simulates role-based collaboration among educational agents to produce cohesive and pedagogically aligned content. The system operates in four modes: Autonomous, Catalog-Guided, Feedback-Guided, and Full Co-Pilot mode, enabling flexible control over the degree of human involvement. We evaluate Instructional Agents across five university-level computer science courses and show that it produces high-quality instructional materials while significantly reducing development time and human workload. By supporting institutions with limited instructional design capacity, Instructional Agents provides a scalable and cost-effective framework to democratize access to high-quality education, particularly in underserved or resource-constrained settings.