Hybrid Vision Transformer-Mamba Framework for Autism Diagnosis via Eye-Tracking Analysis

Accurate Autism Spectrum Disorder (ASD) diagnosis is vital for early intervention. This study presents a hybrid deep learning framework combining Vision Transformers (ViT) and Vision Mamba to detect ASD using eye-tracking data. The model uses attention-based fusion to integrate visual, speech, and facial cues, capturing both spatial and temporal dynamics. Unlike traditional handcrafted methods, it applies state-of-the-art deep learning and explainable AI techniques to enhance diagnostic accuracy and transparency. Tested on the Saliency4ASD dataset, the proposed ViT-Mamba model outperformed existing methods, achieving 0.96 accuracy, 0.95 F1-score, 0.97 sensitivity, and 0.94 specificity. These findings show the model's promise for scalable, interpretable ASD screening, especially in resource-constrained or remote clinical settings where access to expert diagnosis is limited.

Exploring Image Transforms derived from Eye Gaze Variables for Progressive Autism Diagnosis

The prevalence of Autism Spectrum Disorder (ASD) has surged rapidly over the past decade, posing significant challenges in communication, behavior, and focus for affected individuals. Current diagnostic techniques, though effective, are time-intensive, leading to high social and economic costs. This work introduces an AI-powered assistive technology designed to streamline ASD diagnosis and management, enhancing convenience for individuals with ASD and efficiency for caregivers and therapists. The system integrates transfer learning with image transforms derived from eye gaze variables to diagnose ASD. This facilitates and opens opportunities for in-home periodical diagnosis, reducing stress for individuals and caregivers, while also preserving user privacy through the use of image transforms. The accessibility of the proposed method also offers opportunities for improved communication between guardians and therapists, ensuring regular updates on progress and evolving support needs. Overall, the approach proposed in this work ensures timely, accessible diagnosis while protecting the subjects' privacy, improving outcomes for individuals with ASD.

Predicting Patient COVID-19 Disease Severity by means of Statistical and Machine Learning Analysis of Blood Cell Transcriptome Data

Introduction: For COVID-19 patients accurate prediction of disease severity and mortality risk would greatly improve care delivery and resource allocation. There are many patient-related factors, such as pre-existing comorbidities that affect disease severity. Since rapid automated profiling of peripheral blood samples is widely available, we investigated how such data from the peripheral blood of COVID-19 patients might be used to predict clinical outcomes. Methods: We thus investigated such clinical datasets from COVID-19 patients with known outcomes by combining statistical comparison and correlation methods with machine learning algorithms; the latter included decision tree, random forest, variants of gradient boosting machine, support vector machine, K-nearest neighbour and deep learning methods. Results: Our work revealed several clinical parameters measurable in blood samples, which discriminated between healthy people and COVID-19 positive patients and showed predictive value for later severity of COVID-19 symptoms. We thus developed a number of analytic methods that showed accuracy and precision for disease severity and mortality outcome predictions that were above 90%. Conclusions: In sum, we developed methodologies to analyse patient routine clinical data which enables more accurate prediction of COVID-19 patient outcomes. This type of approaches could, by employing standard hospital laboratory analyses of patient blood, be utilised to identify, COVID-19 patients at high risk of mortality and so enable their treatment to be optimised.

Machine Learning and Meta-Analysis Approach to Identify Patient Comorbidities and Symptoms that Increased Risk of Mortality in COVID-19

Background: Providing appropriate care for people suffering from COVID-19, the disease caused by the pandemic SARS-CoV-2 virus is a significant global challenge. Many individuals who become infected have pre-existing conditions that may interact with COVID-19 to increase symptom severity and mortality risk. COVID-19 patient comorbidities are likely to be informative about individual risk of severe illness and mortality. Accurately determining how comorbidities are associated with severe symptoms and mortality would thus greatly assist in COVID-19 care planning and provision. Methods: To assess the interaction of patient comorbidities with COVID-19 severity and mortality we performed a meta-analysis of the published global literature, and machine learning predictive analysis using an aggregated COVID-19 global dataset. Results: Our meta-analysis identified chronic obstructive pulmonary disease (COPD), cerebrovascular disease (CEVD), cardiovascular disease (CVD), type 2 diabetes, malignancy, and hypertension as most significantly associated with COVID-19 severity in the current published literature. Machine learning classification using novel aggregated cohort data similarly found COPD, CVD, CKD, type 2 diabetes, malignancy and hypertension, as well as asthma, as the most significant features for classifying those deceased versus those who survived COVID-19. While age and gender were the most significant predictor of mortality, in terms of symptom-comorbidity combinations, it was observed that Pneumonia-Hypertension, Pneumonia-Diabetes and Acute Respiratory Distress Syndrome (ARDS)-Hypertension showed the most significant effects on COVID-19 mortality. Conclusions: These results highlight patient cohorts most at risk of COVID-19 related severe morbidity and mortality which have implications for prioritization of hospital resources.