A Cross-Layered Multi-Drone Coordination for Medical Supply Delivery during Disaster Response Management

Autonomous drone fleets have immense potential in medical supply delivery during disaster incident response. However, coordinating multiple drones in such settings introduces compounding challenges: dynamic environmental hazards such as wind, obstacles, and intermittent network connectivity, constrained energy budgets, and the need to serve patient locations fairly under deadlines and triage-based priority while optimizing schedule utilization. In this paper, we present CEDA, a novel CTDE Deep Q-Network algorithm for cooperative multi-drone medical delivery, designed to jointly optimize triage-priority-aware routing, multi-agent coordination, and energy-efficient navigation under dynamic uncertainty. CEDA introduces a Priority-Preserving Fair Scheduling strategy, in which a structured reward function encodes both triage weights and complementary fairness mechanisms ensuring no patient class is starved of service. We evaluate CEDA in a simulated grid environment featuring dynamic hazard zones, stochastic action failures, and dynamically spawning patients across three triage priority levels, as well as in a PX4 SITL validation using two X500 quadrotors controlled via MAVSDK in offboard position mode. Simulation results demonstrate that CEDA achieves a delivery completion rate above 85%, reduces obstacle collisions by over 90% across training, and delivers an average of 6 patients per episode with a triage efficiency of 0.82. CEDA preserves clinical priority ordering, Critical patients are served first, while achieving near-zero mortality across lower-triage classes, confirming that priority-weighted routing does not condemn Stable or Urgent patients to neglect. PX4 SITL validation further demonstrates that the learned policy remains executable and triage-coherent under practical communication constraints and realistic multi-drone coordination in disaster response settings.