Towards Efficient Information Fusion: Concentric Dual Fusion Attention Based Multiple Instance Learning for Whole Slide Images

In the realm of digital pathology, multi-magnification Multiple Instance Learning (multi-mag MIL) has proven effective in leveraging the hierarchical structure of Whole Slide Images (WSIs) to reduce information loss and redundant data. However, current methods fall short in bridging the domain gap between pretrained models and medical imaging, and often fail to account for spatial relationships across different magnifications. Addressing these challenges, we introduce the Concentric Dual Fusion Attention-MIL (CDFA-MIL) framework,which innovatively combines point-to-area feature-colum attention and point-to-point concentric-row attention using concentric patch. This approach is designed to effectively fuse correlated information, enhancing feature representation and providing stronger correlation guidance for WSI analysis. CDFA-MIL distinguishes itself by offering a robust fusion strategy that leads to superior WSI recognition. Its application has demonstrated exceptional performance, significantly surpassing existing MIL methods in accuracy and F1 scores on prominent datasets like Camelyon16 and TCGA-NSCLC. Specifically, CDFA-MIL achieved an average accuracy and F1-score of 93.7\% and 94.1\% respectively on these datasets, marking a notable advancement over traditional MIL approaches.