NEMESIS: Noise-suppressed Efficient MAE with Enhanced Superpatch Integration Strategy

Volumetric CT imaging is essential for clinical diagnosis, yet annotating 3D volumes is expensive and time-consuming, motivating self-supervised learning (SSL) from unlabeled data. However, applying SSL to 3D CT remains challenging due to the high memory cost of full-volume transformers and the anisotropic spatial structure of CT data, which is not well captured by conventional masking strategies. We propose NEMESIS, a masked autoencoder (MAE) framework that operates on local 128x128x128 superpatches, enabling memory-efficient training while preserving anatomical detail. NEMESIS introduces three key components: (i) noise-enhanced reconstruction as a pretext task, (ii) Masked Anatomical Transformer Blocks (MATB) that perform dual-masking through parallel plane-wise and axis-wise token removal, and (iii) NEMESIS Tokens (NT) for cross-scale context aggregation. On the BTCV multi-organ classification benchmark, NEMESIS with a frozen backbone and a linear classifier achieves a mean AUROC of 0.9633, surpassing fully fine-tuned SuPreM (0.9493) and VoCo (0.9387). Under a low-label regime with only 10% of available annotations, it retains an AUROC of 0.9075, demonstrating strong label efficiency. Furthermore, the superpatch-based design reduces computational cost to 31.0 GFLOPs per forward pass, compared to 985.8 GFLOPs for the full-volume baseline, providing a scalable and robust foundation for 3D medical imaging.

MATHENA: Mamba-based Architectural Tooth Hierarchical Estimator and Holistic Evaluation Network for Anatomy

Dental diagnosis from Orthopantomograms (OPGs) requires coordination of tooth detection, caries segmentation (CarSeg), anomaly detection (AD), and dental developmental staging (DDS). We propose Mamba-based Architectural Tooth Hierarchical Estimator and Holistic Evaluation Network for Anatomy (MATHENA), a unified framework leveraging Mamba's linear-complexity State Space Models (SSM) to address all four tasks. MATHENA integrates MATHE, a multi-resolution SSM-driven detector with four-directional Vision State Space (VSS) blocks for O(N) global context modeling, generating per-tooth crops. These crops are processed by HENA, a lightweight Mamba-UNet with a triple-head architecture and Global Context State Token (GCST). In the triple-head architecture, CarSeg is first trained as an upstream task to establish shared representations, which are then frozen and reused for downstream AD fine-tuning and DDS classification via linear probing, enabling stable, efficient learning. We also curate PARTHENON, a benchmark comprising 15,062 annotated instances from ten datasets. MATHENA achieves 93.78% mAP@50 in tooth detection, 90.11% Dice for CarSeg, 88.35% for AD, and 72.40% ACC for DDS.

MAESIL: Masked Autoencoder for Enhanced Self-supervised Medical Image Learning

Training deep learning models for three-dimensional (3D) medical imaging, such as Computed Tomography (CT), is fundamentally challenged by the scarcity of labeled data. While pre-training on natural images is common, it results in a significant domain shift, limiting performance. Self-Supervised Learning (SSL) on unlabeled medical data has emerged as a powerful solution, but prominent frameworks often fail to exploit the inherent 3D nature of CT scans. These methods typically process 3D scans as a collection of independent 2D slices, an approach that fundamentally discards critical axial coherence and the 3D structural context. To address this limitation, we propose the autoencoder for enhanced self-supervised medical image learning(MAESIL), a novel self-supervised learning framework designed to capture 3D structural information efficiently. The core innovation is the 'superpatch', a 3D chunk-based input unit that balances 3D context preservation with computational efficiency. Our framework partitions the volume into superpatches and employs a 3D masked autoencoder strategy with a dual-masking strategy to learn comprehensive spatial representations. We validated our approach on three diverse large-scale public CT datasets. Our experimental results show that MAESIL demonstrates significant improvements over existing methods such as AE, VAE and VQ-VAE in key reconstruction metrics such as PSNR and SSIM. This establishes MAESIL as a robust and practical pre-training solution for 3D medical imaging tasks.

SuperPure: Efficient Purification of Localized and Distributed Adversarial Patches via Super-Resolution GAN Models

As vision-based machine learning models are increasingly integrated into autonomous and cyber-physical systems, concerns about (physical) adversarial patch attacks are growing. While state-of-the-art defenses can achieve certified robustness with minimal impact on utility against highly-concentrated localized patch attacks, they fall short in two important areas: (i) State-of-the-art methods are vulnerable to low-noise distributed patches where perturbations are subtly dispersed to evade detection or masking, as shown recently by the DorPatch attack; (ii) Achieving high robustness with state-of-the-art methods is extremely time and resource-consuming, rendering them impractical for latency-sensitive applications in many cyber-physical systems. To address both robustness and latency issues, this paper proposes a new defense strategy for adversarial patch attacks called SuperPure. The key novelty is developing a pixel-wise masking scheme that is robust against both distributed and localized patches. The masking involves leveraging a GAN-based super-resolution scheme to gradually purify the image from adversarial patches. Our extensive evaluations using ImageNet and two standard classifiers, ResNet and EfficientNet, show that SuperPure advances the state-of-the-art in three major directions: (i) it improves the robustness against conventional localized patches by more than 20%, on average, while also improving top-1 clean accuracy by almost 10%; (ii) It achieves 58% robustness against distributed patch attacks (as opposed to 0% in state-of-the-art method, PatchCleanser); (iii) It decreases the defense end-to-end latency by over 98% compared to PatchCleanser. Our further analysis shows that SuperPure is robust against white-box attacks and different patch sizes. Our code is open-source.

LightPure: Realtime Adversarial Image Purification for Mobile Devices Using Diffusion Models

Autonomous mobile systems increasingly rely on deep neural networks for perception and decision-making. While effective, these systems are vulnerable to adversarial machine learning attacks where minor input perturbations can significantly impact outcomes. Common countermeasures involve adversarial training and/or data or network transformation. These methods, though effective, require full access to typically proprietary classifiers and are costly for large models. Recent solutions propose purification models, which add a "purification" layer before classification, eliminating the need to modify the classifier directly. Despite their effectiveness, these methods are compute-intensive, making them unsuitable for mobile systems where resources are limited and low latency is essential. This paper introduces LightPure, a new method that enhances adversarial image purification. It improves the accuracy of existing purification methods and provides notable enhancements in speed and computational efficiency, making it suitable for mobile devices with limited resources. Our approach uses a two-step diffusion and one-shot Generative Adversarial Network (GAN) framework, prioritizing latency without compromising robustness. We propose several new techniques to achieve a reasonable balance between classification accuracy and adversarial robustness while maintaining desired latency. We design and implement a proof-of-concept on a Jetson Nano board and evaluate our method using various attack scenarios and datasets. Our results show that LightPure can outperform existing methods by up to 10x in terms of latency while achieving higher accuracy and robustness for various attack scenarios. This method offers a scalable and effective solution for real-world mobile systems.