Detecting seizure onset and offset times using human intelligence: A critical-transitions-based approach

Most existing seizure detection algorithms require extensive pre-processing of the data and rely on heuristic or currently unexplainable machine learning approaches. These approaches often struggle with balancing detection sensitivity and specificity in the presence of variable seizure morphologies, interictal epileptiform discharges, and artefacts. Here, we consider an alternative approach: our seizure detection algorithm, which is based on the concept of critical transitions and overcomes the aforementioned limitations. Specifically, we perform a receiver-operating-characteristic analysis to quantify the performance of our algorithm in terms of its agreement with expert annotations of seizure onset and offset times in the voltage recordings of seizure activity in epileptic rodents with different seizure morphologies. We demonstrate how performance depends on algorithm parameters and varies across different rodent recording sessions. We determine the optimal set of algorithm parameters for each recording session, with near expert-level performance achieved in most cases. Finally, we derive a single general set of algorithm parameters applicable across all recording sessions. The algorithm maintains its high performance in this general setting, demonstrating its versatility, robustness across varying seizure morphologies, and potential to complement machine learning algorithms.

The Headless Firm: How AI Reshapes Enterprise Boundaries

The boundary of the firm is determined by coordination cost. We argue that agentic AI induces a structural change in how coordination costs scale: in prior modular systems, integration cost grew with interaction topology (O(n^2) in the number of components); in protocol-mediated agentic systems, integration cost collapses to O(n) while verification scales with task throughput rather than interaction count. This shift selects for a specific organizational equilibrium -- the Headless Firm -- structured as an hourglass: a personalized generative interface at the top, a standardized protocol waist in the middle, and a competitive market of micro-specialized execution agents at the bottom. We formalize this claim as a coordination cost model with two falsifiable empirical predictions: (1) the marginal cost of adding an execution provider should be approximately constant in a mature hourglass ecosystem; (2) the ratio of total coordination cost to task throughput should remain stable as ecosystem size grows. We derive conditions for hourglass stability versus re-centralization and analyze implications for firm size distributions, labor markets, and software economics. The analysis predicts a domain-conditional Great Unbundling: in high knowledge-velocity domains, firm size distributions shift mass from large integrated incumbents toward micro-specialized agents and thin protocol orchestrators.