Locating Hidden Exoplanets in ALMA Data Using Machine Learning

Exoplanets in protoplanetary disks cause localized deviations from Keplerian velocity in channel maps of molecular line emission. Current methods of characterizing these deviations are time consuming, and there is no unified standard approach. We demonstrate that machine learning can quickly and accurately detect the presence of planets. We train our model on synthetic images generated from simulations and apply it to real observations to identify forming planets in real systems. Machine learning methods, based on computer vision, are not only capable of correctly identifying the presence of one or more planets, but they can also correctly constrain the location of those planets.

CathAI: Fully Automated Interpretation of Coronary Angiograms Using Neural Networks

Coronary heart disease (CHD) is the leading cause of adult death in the United States and worldwide, and for which the coronary angiography procedure is the primary gateway for diagnosis and clinical management decisions. The standard-of-care for interpretation of coronary angiograms depends upon ad-hoc visual assessment by the physician operator. However, ad-hoc visual interpretation of angiograms is poorly reproducible, highly variable and bias prone. Here we show for the first time that fully-automated angiogram interpretation to estimate coronary artery stenosis is possible using a sequence of deep neural network algorithms. The algorithmic pipeline we developed--called CathAI--achieves state-of-the art performance across the sequence of tasks required to accomplish automated interpretation of unselected, real-world angiograms. CathAI (Algorithms 1-2) demonstrated positive predictive value, sensitivity and F1 score of >=90% to identify the projection angle overall and >=93% for left or right coronary artery angiogram detection, the primary anatomic structures of interest. To predict obstructive coronary artery stenosis (>=70% stenosis), CathAI (Algorithm 4) exhibited an area under the receiver operating characteristic curve (AUC) of 0.862 (95% CI: 0.843-0.880). When externally validated in a healthcare system in another country, CathAI AUC was 0.869 (95% CI: 0.830-0.907) to predict obstructive coronary artery stenosis. Our results demonstrate that multiple purpose-built neural networks can function in sequence to accomplish the complex series of tasks required for automated analysis of real-world angiograms. Deployment of CathAI may serve to increase standardization and reproducibility in coronary stenosis assessment, while providing a robust foundation to accomplish future tasks for algorithmic angiographic interpretation.