Abstract:The complexities of healthcare data, including privacy concerns, imbalanced datasets, and interoperability issues, necessitate innovative machine learning solutions. Swarm Learning (SL), a decentralized alternative to Federated Learning, offers privacy-preserving distributed training, but its reliance on blockchain technology hinders accessibility and scalability. This paper introduces a \textit{Simplified Peer-to-Peer Swarm Learning (P2P-SL) Framework} tailored for resource-constrained environments. By eliminating blockchain dependencies and adopting lightweight peer-to-peer communication, the proposed framework ensures robust model synchronization while maintaining data privacy. Applied to cancer histopathology, the framework integrates optimized pre-trained models, such as TorchXRayVision, enhanced with DenseNet decoders, to improve diagnostic accuracy. Extensive experiments demonstrate the framework's efficacy in handling imbalanced and biased datasets, achieving comparable performance to centralized models while preserving privacy. This study paves the way for democratizing advanced machine learning in healthcare, offering a scalable, accessible, and efficient solution for privacy-sensitive diagnostic applications.