CaMBRAIN: Real-time, Continuous EEG Inference with Causal State Space Models

Electroencephalography (EEG) is a critical, non-invasive method to monitor electrical brain activity. EEGs can span anywhere from a couple seconds to multiple hours, posing a major hurdle for existing deep learning methods due to two major factors: (1) existing EEG models are predominantly built upon the attention mechanism, incurring quadratic scaling as the sequence length increases, and (2) raw EEG signals must be processed in a sliding-window fashion due to fixed-length input requirements, preventing global understanding of the entire signal. To this extent, we propose CaMBRAIN - the first Causal, Mamba-based state space model (SSM) capable of real-time inference of EEG signals, arguing that bidirectional approaches are needlessly expensive given the causal, unidirectional nature of EEG. However, training such a model is non-trivial, as crucial EEG events can be extremely brief - within fractions of a second - yet separated by long intervals spanning minutes. Current EEG methods use self-supervised objectives that optimize for signal reconstruction, but these are not well suited for streaming SSMs; they fail to explicitly train the hidden state to retain the salient long-range context needed for streaming inference. We therefore introduce a multi-stage self-supervised training pipeline specifically tailored to encourage long-range memory retention and strong performance on EEG signals, while preserving the linear-time complexity of state space models. CaMBRAIN achieves state-of-the-art (SOTA) results across 3 different EEG datasets with >10x higher throughput than existing models, enabling the first model capable of long-range, continuous inference of variable-length EEG signals.

Enhancing Box and Block Test with Computer Vision for Post-Stroke Upper Extremity Motor Evaluation

Standard clinical assessments of upper-extremity motor function after stroke either rely on ordinal scoring, which lacks sensitivity, or time-based task metrics, which do not capture movement quality. In this work, we present a computer vision-based framework for analysis of upper-extremity movement during the Box and Block Test (BBT) through world-aligned joint angles of fingers, arm, and trunk without depth sensors or calibration objects. We apply this framework to a dataset of 136 BBT recordings collected from 48 healthy individuals and 7 individuals post stroke. Using unsupervised dimensionality reduction of joint-angle features, we analyze movement patterns without relying on expert clinical labels. The resulting embeddings show separation between healthy movement patterns and stroke-related movement deviations. Importantly, some patients with the same BBT scores can be separated with different postural patterns. These results show that world-aligned joint angles can capture meaningful information of upper-extremity functions beyond standard time-based BBT scores, with no effort from the clinician other than monocular video recordings of the patient using a phone or camera. This work highlights the potential of a camera-based, calibration-free framework to measure movement quality in clinical assessments without changing the widely adopted clinical routine.