T-CACE: A Time-Conditioned Autoregressive Contrast Enhancement Multi-Task Framework for Contrast-Free Liver MRI Synthesis, Segmentation, and Diagnosis

Magnetic resonance imaging (MRI) is a leading modality for the diagnosis of liver cancer, significantly improving the classification of the lesion and patient outcomes. However, traditional MRI faces challenges including risks from contrast agent (CA) administration, time-consuming manual assessment, and limited annotated datasets. To address these limitations, we propose a Time-Conditioned Autoregressive Contrast Enhancement (T-CACE) framework for synthesizing multi-phase contrast-enhanced MRI (CEMRI) directly from non-contrast MRI (NCMRI). T-CACE introduces three core innovations: a conditional token encoding (CTE) mechanism that unifies anatomical priors and temporal phase information into latent representations; and a dynamic time-aware attention mask (DTAM) that adaptively modulates inter-phase information flow using a Gaussian-decayed attention mechanism, ensuring smooth and physiologically plausible transitions across phases. Furthermore, a constraint for temporal classification consistency (TCC) aligns the lesion classification output with the evolution of the physiological signal, further enhancing diagnostic reliability. Extensive experiments on two independent liver MRI datasets demonstrate that T-CACE outperforms state-of-the-art methods in image synthesis, segmentation, and lesion classification. This framework offers a clinically relevant and efficient alternative to traditional contrast-enhanced imaging, improving safety, diagnostic efficiency, and reliability for the assessment of liver lesion. The implementation of T-CACE is publicly available at: https://github.com/xiaojiao929/T-CACE.

Pyramid Hierarchical Masked Diffusion Model for Imaging Synthesis

Medical image synthesis plays a crucial role in clinical workflows, addressing the common issue of missing imaging modalities due to factors such as extended scan times, scan corruption, artifacts, patient motion, and intolerance to contrast agents. The paper presents a novel image synthesis network, the Pyramid Hierarchical Masked Diffusion Model (PHMDiff), which employs a multi-scale hierarchical approach for more detailed control over synthesizing high-quality images across different resolutions and layers. Specifically, this model utilizes randomly multi-scale high-proportion masks to speed up diffusion model training, and balances detail fidelity and overall structure. The integration of a Transformer-based Diffusion model process incorporates cross-granularity regularization, modeling the mutual information consistency across each granularity's latent spaces, thereby enhancing pixel-level perceptual accuracy. Comprehensive experiments on two challenging datasets demonstrate that PHMDiff achieves superior performance in both the Peak Signal-to-Noise Ratio (PSNR) and Structural Similarity Index Measure (SSIM), highlighting its capability to produce high-quality synthesized images with excellent structural integrity. Ablation studies further confirm the contributions of each component. Furthermore, the PHMDiff model, a multi-scale image synthesis framework across and within medical imaging modalities, shows significant advantages over other methods. The source code is available at https://github.com/xiaojiao929/PHMDiff

FgC2F-UDiff: Frequency-guided and Coarse-to-fine Unified Diffusion Model for Multi-modality Missing MRI Synthesis

Multi-modality magnetic resonance imaging (MRI) is essential for the diagnosis and treatment of brain tumors. However, missing modalities are commonly observed due to limitations in scan time, scan corruption, artifacts, motion, and contrast agent intolerance. Synthesis of missing MRI has been a means to address the limitations of modality insufficiency in clinical practice and research. However, there are still some challenges, such as poor generalization, inaccurate non-linear mapping, and slow processing speeds. To address the aforementioned issues, we propose a novel unified synthesis model, the Frequency-guided and Coarse-to-fine Unified Diffusion Model (FgC2F-UDiff), designed for multiple inputs and outputs. Specifically, the Coarse-to-fine Unified Network (CUN) fully exploits the iterative denoising properties of diffusion models, from global to detail, by dividing the denoising process into two stages, coarse and fine, to enhance the fidelity of synthesized images. Secondly, the Frequency-guided Collaborative Strategy (FCS) harnesses appropriate frequency information as prior knowledge to guide the learning of a unified, highly non-linear mapping. Thirdly, the Specific-acceleration Hybrid Mechanism (SHM) integrates specific mechanisms to accelerate the diffusion model and enhance the feasibility of many-to-many synthesis. Extensive experimental evaluations have demonstrated that our proposed FgC2F-UDiff model achieves superior performance on two datasets, validated through a comprehensive assessment that includes both qualitative observations and quantitative metrics, such as PSNR SSIM, LPIPS, and FID.

AlzheimerRAG: Multimodal Retrieval Augmented Generation for PubMed articles

Recent advancements in generative AI have flourished the development of highly adept Large Language Models (LLMs) that integrate diverse data types to empower decision-making. Among these, Multimodal Retrieval-Augmented Generation (RAG) applications are promising for their capability to combine the strengths of information retrieval and generative models, enhancing their utility across various domains, including biomedical research. This paper introduces AlzheimerRAG, a Multimodal RAG pipeline tool for biomedical research use cases, primarily focusing on Alzheimer's disease from PubMed articles. Our pipeline incorporates multimodal fusion techniques to integrate textual and visual data processing by efficiently indexing and accessing vast amounts of biomedical literature. Preliminary experimental results against benchmarks, such as BioASQ and PubMedQA, have returned improved results in information retrieval and synthesis of domain-specific information. We also demonstrate a case study with our RAG pipeline across different Alzheimer's clinical scenarios. We infer that AlzheimerRAG can generate responses with accuracy non-inferior to humans and with low rates of hallucination. Overall, a reduction in cognitive task load is observed, which allows researchers to gain multimodal insights, improving understanding and treatment of Alzheimer's disease.

DragonVerseQA: Open-Domain Long-Form Context-Aware Question-Answering

This paper proposes a novel approach to develop an open-domain and long-form Over-The-Top (OTT) Question-Answering (QA) dataset, DragonVerseQA, specifically oriented to the fantasy universe of "House of the Dragon" and "Game Of Thrones" TV series. Most existing QA datasets focus on short, fact-based answers sourced almost solely from Wikipedia articles, devoid of depth and contextual richness for sophisticated narrative understanding. We curate a dataset that combines full episode summaries sourced from HBO and fandom wiki websites, user reviews from sources like IMDb and Rotten Tomatoes, and high-quality, open-domain, legally admissible sources, and structured data from repositories like WikiData into one dataset. The dataset provides a multi-dimensional context, reflecting complex character dynamics and plot developments from these varied sources. That means, on equal footing, only after heavy data preprocessing and filtering methods will meaningful, non-spam unbiased reviews be available in this enriched dataset. The comprehensive insights are given through the long-form answers generated from this enriched context. This is what makes this valuable dataset for improving conversational AI, narrative analysis, sentiment analysis, summarization techniques, and relation extraction. A comparative analysis with state-of-the-art QA datasets such as SQuAD 2.0, TriviaQA, and Natural Questions brings to light the unique advantages of our dataset in terms of contextual complexity and answer length. Detailed reviews add layers to audience sentiment and narrative interpretation, raising the bar for domain-specific QA with a new quality benchmark. Our work also allows a deeper understanding of entertainment-industry content and opens the door to more knowledgeable and creative AI-driven interactions within digital media environments.

TMU at TREC Clinical Trials Track 2023

This paper describes Toronto Metropolitan University's participation in the TREC Clinical Trials Track for 2023. As part of the tasks, we utilize advanced natural language processing techniques and neural language models in our experiments to retrieve the most relevant clinical trials. We illustrate the overall methodology, experimental settings, and results of our implementation for the run submission as part of Team - V-TorontoMU.