Unpaired Image-to-Image Translation for Segmentation and Signal Unmixing

This work introduces Ui2i, a novel model for unpaired image-to-image translation, trained on content-wise unpaired datasets to enable style transfer across domains while preserving content. Building on CycleGAN, Ui2i incorporates key modifications to better disentangle content and style features, and preserve content integrity. Specifically, Ui2i employs U-Net-based generators with skip connections to propagate localized shallow features deep into the generator. Ui2i removes feature-based normalization layers from all modules and replaces them with approximate bidirectional spectral normalization -- a parameter-based alternative that enhances training stability. To further support content preservation, channel and spatial attention mechanisms are integrated into the generators. Training is facilitated through image scale augmentation. Evaluation on two biomedical tasks -- domain adaptation for nuclear segmentation in immunohistochemistry (IHC) images and unmixing of biological structures superimposed in single-channel immunofluorescence (IF) images -- demonstrates Ui2i's ability to preserve content fidelity in settings that demand more accurate structural preservation than typical translation tasks. To the best of our knowledge, Ui2i is the first approach capable of separating superimposed signals in IF images using real, unpaired training data.

Autonomous particles

Consider a reinforcement learning problem where an agent has access to a very large amount of information about the environment, but it can only take very few actions to accomplish its task and to maximize its reward. Evidently, the main problem for the agent is to learn a map from a very high-dimensional space (which represents its environment) to a very low-dimensional space (which represents its actions). The high-to-low dimensional map implies that most of the information about the environment is irrelevant for the actions to be taken, and only a small fraction of information is relevant. In this paper we argue that the relevant information need not be learned by brute force (which is the standard approach), but can be identified from the intrinsic symmetries of the system. We analyze in details a reinforcement learning problem of autonomous driving, where the corresponding symmetry is the Galilean symmetry, and argue that the learning task can be accomplished with very few relevant parameters, or, more precisely, invariants. For a numerical demonstration, we show that the autonomous vehicles (which we call autonomous particles since they describe very primitive vehicles) need only four relevant invariants to learn how to drive very well without colliding with other particles. The simple model can be easily generalized to include different types of particles (e.g. for cars, for pedestrians, for buildings, for road signs, etc.) with different types of relevant invariants describing interactions between them. We also argue that there must exist a field theory description of the learning system where autonomous particles would be described by fermionic degrees of freedom and interactions mediated by the relevant invariants would be described by bosonic degrees of freedom.