A Hybrid Architecture for Benign-Malignant Classification of Mammography ROIs

Accurate characterization of suspicious breast lesions in mammography is important for early diagnosis and treatment planning. While Convolutional Neural Networks (CNNs) are effective at extracting local visual patterns, they are less suited to modeling long-range dependencies. Vision Transformers (ViTs) address this limitation through self-attention, but their quadratic computational cost can be prohibitive. This paper presents a hybrid architecture that combines EfficientNetV2-M for local feature extraction with Vision Mamba, a State Space Model (SSM), for efficient global context modeling. The proposed model performs binary classification of abnormality-centered mammography regions of interest (ROIs) from the CBIS-DDSM dataset into benign and malignant classes. By combining a strong CNN backbone with a linear-complexity sequence model, the approach achieves strong lesion-level classification performance in an ROI-based setting.