PathSeqSAM: Sequential Modeling for Pathology Image Segmentation with SAM2

Current methods for pathology image segmentation typically treat 2D slices independently, ignoring valuable cross-slice information. We present PathSeqSAM, a novel approach that treats 2D pathology slices as sequential video frames using SAM2's memory mechanisms. Our method introduces a distance-aware attention mechanism that accounts for variable physical distances between slices and employs LoRA for domain adaptation. Evaluated on the KPI Challenge 2024 dataset for glomeruli segmentation, PathSeqSAM demonstrates improved segmentation quality, particularly in challenging cases that benefit from cross-slice context. We have publicly released our code at https://github.com/JackyyyWang/PathSeqSAM.

CTI-Unet: Cascaded Threshold Integration for Improved U-Net Segmentation of Pathology Images

Chronic kidney disease (CKD) is a growing global health concern, necessitating precise and efficient image analysis to aid diagnosis and treatment planning. Automated segmentation of kidney pathology images plays a central role in facilitating clinical workflows, yet conventional segmentation models often require delicate threshold tuning. This paper proposes a novel \textit{Cascaded Threshold-Integrated U-Net (CTI-Unet)} to overcome the limitations of single-threshold segmentation. By sequentially integrating multiple thresholded outputs, our approach can reconcile noise suppression with the preservation of finer structural details. Experiments on the challenging KPIs2024 dataset demonstrate that CTI-Unet outperforms state-of-the-art architectures such as nnU-Net, Swin-Unet, and CE-Net, offering a robust and flexible framework for kidney pathology image segmentation.