DALPHIN: Benchmarking Digital Pathology AI Copilots Against Pathologists on an Open Multicentric Dataset

Foundation models with visual question answering capabilities for digital pathology are emerging. Such unprecedented technology requires independent benchmarking to assess its potential in assisting pathologists in routine diagnostics. We created DALPHIN, the first multicentric open benchmark for pathology AI copilots, comprising 1236 images from 300 cases, spanning 130 rare to common diagnoses, 6 countries, and 14 subspecialties. The DALPHIN design and dataset are introduced alongside a human performance benchmark of 31 pathologists from 10 countries with varying expertise. We report results for two general-purpose (GPT-5, Gemini 2.5 Pro) and one pathology-specific copilot (PathChat+) for sequential and independent answer generation. We observed no statistically significant difference from expert-level performance in four of six tasks for PathChat, 2/6 tasks for Gemini, and 1/6 tasks for GPT. DALPHIN is publicly released with sequestered, indirectly accessible ground truth to foster robust and enduring benchmarking. Data, methods, and the evaluation platform are accessible through dalphin.grand-challenge.org.

Monocular Object Orientation Estimation using Riemannian Regression and Classification Networks

We consider the task of estimating the 3D orientation of an object of known category given an image of the object and a bounding box around it. Recently, CNN-based regression and classification methods have shown significant performance improvements for this task. This paper proposes a new CNN-based approach to monocular orientation estimation that advances the state of the art in four different directions. First, we take into account the Riemannian structure of the orientation space when designing regression losses and nonlinear activation functions. Second, we propose a mixed Riemannian regression and classification framework that better handles the challenging case of nearly symmetric objects. Third, we propose a data augmentation strategy that is specifically designed to capture changes in 3D orientation. Fourth, our approach leads to state-of-the-art results on the PASCAL3D+ dataset.