Institute of Computer Science, University of Bern, Bern, Switzerland, Institute of Digital Technologies for Personalized Healthcare
Abstract:Alcohol-impaired driving remains a major yet preventable cause of road traffic injury and death, with many drivers underestimating their level of intoxication. Compared to in-vehicle systems, mobile drunk-driving detection using consumer smartwatches offers a scalable way to trigger preventive interventions and increase awareness without additional in-vehicle hardware. We introduce a system that leverages wrist accelerometer data and heart rate variability-derived physiological signals to detect alcohol-related driving impairment. We collected data in a randomized, controlled three-arm test-track study (n=54) and trained both logistic regression models with window-aggregated features and a two-tower 1D convolutional neural network (CNN), to detect alcohol-impaired driving. The CNN achieved a participant-averaged area under the receiver operating characteristic (AUROC) of 0.88 for detecting any alcohol intoxication and 0.86 for detecting driving above the WHO-recommended limit of 0.05 g/dL. To the best of our knowledge, this is the first work to (1) demonstrate drunk-driving detection using consumer smartwatches, (2) develop and evaluate such a system in a real vehicle on a closed test track, and (3) rigorously assess generalization to unseen participants. Together, these findings highlight the potential of wearable-based sensing to support scalable, measurement-driven prevention of alcohol-related traffic harm.
Abstract:Despite advances in deep learning for automatic sleep staging, clinical adoption remains limited due to challenges in fair model evaluation, generalization across diverse datasets, model bias, and variability in human annotations. We present SLEEPYLAND, an open-source sleep staging evaluation framework designed to address these barriers. It includes more than 220'000 hours in-domain (ID) sleep recordings, and more than 84'000 hours out-of-domain (OOD) sleep recordings, spanning a broad range of ages, sleep-wake disorders, and hardware setups. We release pre-trained models based on high-performing SoA architectures and evaluate them under standardized conditions across single- and multi-channel EEG/EOG configurations. We introduce SOMNUS, an ensemble combining models across architectures and channel setups via soft voting. SOMNUS achieves robust performance across twenty-four different datasets, with macro-F1 scores between 68.7% and 87.2%, outperforming individual models in 94.9% of cases. Notably, SOMNUS surpasses previous SoA methods, even including cases where compared models were trained ID while SOMNUS treated the same data as OOD. Using a subset of the BSWR (N=6'633), we quantify model biases linked to age, gender, AHI, and PLMI, showing that while ensemble improves robustness, no model architecture consistently minimizes bias in performance and clinical markers estimation. In evaluations on OOD multi-annotated datasets (DOD-H, DOD-O), SOMNUS exceeds the best human scorer, i.e., MF1 85.2% vs 80.8% on DOD-H, and 80.2% vs 75.9% on DOD-O, better reproducing the scorer consensus than any individual expert (k = 0.89/0.85 and ACS = 0.95/0.94 for healthy/OSA cohorts). Finally, we introduce ensemble disagreement metrics - entropy and inter-model divergence based - predicting regions of scorer disagreement with ROC AUCs up to 0.828, offering a data-driven proxy for human uncertainty.

Abstract:Study Objectives: Polysomnography (PSG) currently serves as the benchmark for evaluating sleep disorders. Its discomfort, impracticality for home-use, and introduction of bias in sleep quality assessment necessitate the exploration of less invasive, cost-effective, and portable alternatives. One promising contender is the in-ear-EEG sensor, which offers advantages in terms of comfort, fixed electrode positions, resistance to electromagnetic interference, and user-friendliness. This study aims to establish a methodology to assess the similarity between the in-ear-EEG signal and standard PSG. Methods: We assess the agreement between the PSG and in-ear-EEG derived hypnograms. We extract features in the time- and frequency- domain from PSG and in-ear-EEG 30-second epochs. We only consider the epochs where the PSG-scorers and the in-ear-EEG-scorers were in agreement. We introduce a methodology to quantify the similarity between PSG derivations and the single-channel in-ear-EEG. The approach relies on a comparison of distributions of selected features -- extracted for each sleep stage and subject on both PSG and the in-ear-EEG signals -- via a Jensen-Shannon Divergence Feature-based Similarity Index (JSD-FSI). Results: We found a high intra-scorer variability, mainly due to the uncertainty the scorers had in evaluating the in-ear-EEG signals. We show that the similarity between PSG and in-ear-EEG signals is high (JSD-FSI: 0.61 +/- 0.06 in awake, 0.60 +/- 0.07 in NREM and 0.51 +/- 0.08 in REM), and in line with the similarity values computed independently on standard PSG-channel-combinations. Conclusions: In-ear-EEG is a valuable solution for home-based sleep monitoring, however further studies with a larger and more heterogeneous dataset are needed.




Abstract:Purpose: This study aims to enhance the clinical use of automated sleep-scoring algorithms by incorporating an uncertainty estimation approach to efficiently assist clinicians in the manual review of predicted hypnograms, a necessity due to the notable inter-scorer variability inherent in polysomnography (PSG) databases. Our efforts target the extent of review required to achieve predefined agreement levels, examining both in-domain and out-of-domain data, and considering subjects diagnoses. Patients and methods: Total of 19578 PSGs from 13 open-access databases were used to train U-Sleep, a state-of-the-art sleep-scoring algorithm. We leveraged a comprehensive clinical database of additional 8832 PSGs, covering a full spectrum of ages and sleep-disorders, to refine the U-Sleep, and to evaluate different uncertainty-quantification approaches, including our novel confidence network. The ID data consisted of PSGs scored by over 50 physicians, and the two OOD sets comprised recordings each scored by a unique senior physician. Results: U-Sleep demonstrated robust performance, with Cohen's kappa (K) at 76.2% on ID and 73.8-78.8% on OOD data. The confidence network excelled at identifying uncertain predictions, achieving AUROC scores of 85.7% on ID and 82.5-85.6% on OOD data. Independently of sleep-disorder status, statistical evaluations revealed significant differences in confidence scores between aligning vs discording predictions, and significant correlations of confidence scores with classification performance metrics. To achieve K of at least 90% with physician intervention, examining less than 29.0% of uncertain epochs was required, substantially reducing physicians workload, and facilitating near-perfect agreement.