Simple, Safe, and Overlooked: Reclaiming Sustainable Domain Generalization with Statistical Color Matching

Hardware shifts, color variations, and changing patient characteristics between development and deployment routinely break trained medical image classifiers. Existing remedies fall short: standard color jittering provides insufficient diversity, while deep generative style transfer algorithms hallucinate features, destroy clinically relevant structures, and waste massive compute resources. To address this, we revisit classical statistical color matching and repurpose it as Colorist, a highly efficient data augmentation strategy that applies global mean-standard deviation matching directly in the RGB color space. We demonstrate that this training-free, fully interpretable approach safely generates structurally intact domain variations, outperforming deep generative models in structural fidelity and color alignment. Across out-of-distribution histopathology, peripheral blood, dermatology, and retinal datasets, it improves balanced accuracy by up to +9% over state-of-the-art domain generalization regularizers and by +13% over an unaugmented baseline. Moreover, by avoiding neural networks in the augmentation loop, Colorist preserves anatomical structure, minimizes carbon footprint, and integrates seamlessly into standard dataloaders. Together, these findings establish statistical matching as a safe, interpretable, yet overlooked alternative to deep architectures for clinical robustness. Source code is available at https://github.com/sdoerrich97/colorist.

Vertical Fusion: Condensing Internal Representations for Robust ViT Classification

Despite exposing rich intermediate representations, Vision Transformers (ViTs) are almost exclusively utilized as black-box feature extractors, where only the last layer is considered for downstream tasks. We challenge this convention by introducing the notion of recoverability: the capacity of intermediate representations to correct last-layer failures. By evaluating independent classification probes at every model depth across 16 datasets, we observe that intermediate probes correctly classify 18% to 76% of samples that the last-layer probe misclassifies. We show that these gains are not primarily driven by predictive diversity, but by a redundancy-correctness correspondence, where the internal hierarchy acts as a series of stable, redundant probes of a shared discriminative signal. While established horizontal ensemble strategies (i.e., across multiple models) can improve performance, they incur high computational cost and ignore this vertical signal within a single model. To bridge this gap, we propose VFusion, a principled vertical aggregation strategy employing a learnable mapping into a low-dimensional latent space that synthesizes features across the internal ViT hierarchy. VFusion substantially outperforms established aggregation baselines in both in-distribution and out-of-distribution settings, notably closing 45% of the accuracy gap between the best individual layer and a theoretical oracle performance. Our gains consistently generalize across model sizes and pre-training regimes, confirming that VFusion offers a robust and efficient alternative to horizontal ensemble methods. The code is available at https://github.com/francescodisalvo05/vit-vertical-fusion.