Dendrogram of mixing measures: Hierarchical clustering and model selection for finite mixture models

We present a new way to summarize and select mixture models via the hierarchical clustering tree (dendrogram) constructed from an overfitted latent mixing measure. Our proposed method bridges agglomerative hierarchical clustering and mixture modeling. The dendrogram's construction is derived from the theory of convergence of the mixing measures, and as a result, we can both consistently select the true number of mixing components and obtain the pointwise optimal convergence rate for parameter estimation from the tree, even when the model parameters are only weakly identifiable. In theory, it explicates the choice of the optimal number of clusters in hierarchical clustering. In practice, the dendrogram reveals more information on the hierarchy of subpopulations compared to traditional ways of summarizing mixture models. Several simulation studies are carried out to support our theory. We also illustrate the methodology with an application to single-cell RNA sequence analysis.

Strong identifiability and parameter learning in regression with heterogeneous response

Mixtures of regression are a powerful class of models for regression learning with respect to a highly uncertain and heterogeneous response variable of interest. In addition to being a rich predictive model for the response given some covariates, the parameters in this model class provide useful information about the heterogeneity in the data population, which is represented by the conditional distributions for the response given the covariates associated with a number of distinct but latent subpopulations. In this paper, we investigate conditions of strong identifiability, rates of convergence for conditional density and parameter estimation, and the Bayesian posterior contraction behavior arising in finite mixture of regression models, under exact-fitted and over-fitted settings and when the number of components is unknown. This theory is applicable to common choices of link functions and families of conditional distributions employed by practitioners. We provide simulation studies and data illustrations, which shed some light on the parameter learning behavior found in several popular regression mixture models reported in the literature.