Query-Conditioned Knowledge Alignment for Reliable Cross-System Medical Reasoning

Cross-domain knowledge alignment is essential for integrating heterogeneous medical systems, yet existing approaches typically treat entity alignment as a static matching problem, ignoring query context and cross-system asymmetry. This limitation is particularly critical in integrative medical settings, where correspondence between concepts is inherently context-dependent, non-bijective, and direction-sensitive. In this paper, we propose Query-Conditioned Entity Alignment (QCEA), which reformulates entity alignment as a query-conditioned correspondence problem. Instead of learning a fixed mapping between entity representations, QCEA treats the textual description of a source entity as a query and ranks candidate entities in the target graph, enabling context-dependent alignment. The framework integrates semantic encoding, graph-based representation learning, and a direction-aware transformation module to capture asymmetric and many-to-many correspondence across heterogeneous knowledge systems. We evaluate QCEA on TCM--WM knowledge graphs derived from SymMap, covering both symptom alignment and herb--molecule alignment tasks. Experimental results show consistent improvements over representative baselines, particularly on rank-sensitive metrics such as Hit@K and MRR. Furthermore, downstream retrieval-augmented generation (RAG) experiments demonstrate that improved alignment leads to better evidence retrieval, stronger grounding, and higher answer accuracy. These findings highlight that alignment is not merely a data integration step, but a key factor that shapes knowledge accessibility and reliability in cross-system medical reasoning.

Geometrical Cross-Attention and Nonvoid Voxelization for Efficient 3D Medical Image Segmentation

Accurate segmentation of 3D medical scans is crucial for clinical diagnostics and treatment planning, yet existing methods often fail to achieve both high accuracy and computational efficiency across diverse anatomies and imaging modalities. To address these challenges, we propose GCNV-Net, a novel 3D medical segmentation framework that integrates a Tri-directional Dynamic Nonvoid Voxel Transformer (3DNVT), a Geometrical Cross-Attention module (GCA), and Nonvoid Voxelization. The 3DNVT dynamically partitions relevant voxels along the three orthogonal anatomical planes, namely the transverse, sagittal, and coronal planes, enabling effective modeling of complex 3D spatial dependencies. The GCA mechanism explicitly incorporates geometric positional information during multi-scale feature fusion, significantly enhancing fine-grained anatomical segmentation accuracy. Meanwhile, Nonvoid Voxelization processes only informative regions, greatly reducing redundant computation without compromising segmentation quality, and achieves a 56.13% reduction in FLOPs and a 68.49% reduction in inference latency compared to conventional voxelization. We evaluate GCNV-Net on multiple widely used benchmarks: BraTS2021, ACDC, MSD Prostate, MSD Pancreas, and AMOS2022. Our method achieves state-of-the-art segmentation performance across all datasets, outperforming the best existing methods by 0.65% on Dice, 0.63% on IoU, 1% on NSD, and relatively 14.5% on HD95. All results demonstrate that GCNV-Net effectively balances accuracy and efficiency, and its robustness across diverse organs, disease conditions, and imaging modalities highlights strong potential for clinical deployment.

From Snapshot Sensing to Persistent EM World Modeling: A Generative-Space Perspective for ISAC

Electromagnetic (EM) world modeling is emerging as a foundational capability for environment-aware and embodiment-enabled wireless systems. However, most existing mmWave sensing solutions are designed for snapshot-based parameter estimation and rely on hardware-intensive architectures, making scalable and persistent world modeling difficult to achieve. This article rethinks mmWave sensing from a system-level perspective and introduces a generative-space framework, in which sensing is realized through controlled traversal of a low-dimensional excitation space spanning frequency, waveform, and physical embodiment. This perspective decouples spatial observability from rigid antenna arrays and transmit-time multiplexing, enabling flexible and scalable sensing-by-design radios. To illustrate the practicality of this framework, we present a representative realization called Multi-RF Chain Frequency-as-Aperture Clip-on Aperture Fabric (MRC-FaA-CAF), where multiple FMCW sources coordinate frequency-selective modules distributed along guided-wave backbones. This architecture enables interference-free excitation, preserves beat-frequency separability, and maintains low calibration overhead. Case studies show that generative-space-driven sensing can achieve update rates comparable to phased arrays while avoiding dense RF replication and the latency penalties of TDM-MIMO systems. Overall, this work positions generative-space-driven sensing as a practical architectural foundation for mmWave systems that move beyond snapshot sensing toward persistent EM world modeling.