Classifying the Valence of Autobiographical Memories from fMRI Data

We show that fMRI analysis using machine learning tools are sufficient to distinguish valence (i.e., positive or negative) of freely retrieved autobiographical memories in a cross-participant setting. Our methodology uses feature selection (ReliefF) in combination with boosting methods, both applied directly to data represented in voxel space. In previous work using the same data set, Nawa and Ando showed that whole-brain based classification could achieve above-chance classification accuracy only when both training and testing data came from the same individual. In a cross-participant setting, classification results were not statistically significant. Additionally, on average the classification accuracy obtained when using ReliefF is substantially higher than previous results - 81% for the within-participant classification, and 62% for the cross-participant classification. Furthermore, since features are defined in voxel space, it is possible to show brain maps indicating the regions of that are most relevant in determining the results of the classification. Interestingly, the voxels that were selected using the proposed computational pipeline seem to be consistent with current neurophysiological theories regarding the brain regions actively involved in autobiographical memory processes.

Features and Machine Learning for Correlating and Classifying between Brain Areas and Dyslexia

We develop a method that is based on processing gathered Event Related Potentials (ERP) signals and the use of machine learning technique for multivariate analysis (i.e. classification) that we apply in order to analyze the differences between Dyslexic and Skilled readers. No human intervention is needed in the analysis process. This is the state of the art results for automatic identification of Dyslexic readers using a Lexical Decision Task. We use mathematical and machine learning based techniques to automatically discover novel complex features that (i) allow for reliable distinction between Dyslexic and Normal Control Skilled readers and (ii) to validate the assumption that the most of the differences between Dyslexic and Skilled readers located in the left hemisphere. Interestingly, these tools also pointed to the fact that High Pass signals (typically considered as "noise" during ERP/EEG analyses) in fact contains significant relevant information. Finally, the proposed scheme can be used for analysis of any ERP based studies.